the present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

Amlodipine besylate microspheres for intranasal administration were prepared with an aim to avoid first-pass metabolism, to achieve controlled blood level profiles and to improve therapeutic efficacy. Hydroxypropyl Guar, a biodegradable polymer, was used in the preparation of microspheres by employing water in oil emulsification solvent evaporation technique. The formulation variables were drug...

Pharmaceutical scientists around the globe have been seeking to discover as an alternative injections over last few, transdermal and transmucosal routes decades. The buccal cavity mucosa most convenient easily available site for distribution of local systemic therapeutic agents was found be dosage forms among numerous sitesavailable.Theories various polymers used in mucoadhesive drug delivery. ...

The aim of this study was to develop and characterize chitosan microspheres Carvedilol (CRV) for nasal delivery improve bioavailability treatment hypertension angina pectoris. comes under BCS class II, is poorly water soluble drug highly permeable. Solubility determined by shaking flask method lipophilicity separating funnel method. route very convenient achieving high reduce hepatic first pass...

Pluronic-PAA, a thermogelling copolymer composed of side chains of poly(acrylic acid) (PAA) grafted onto a backbone of Pluronic copolymer, is of interest as a vehicle for the controlled release of compounds. An important feature of such a vehicle is its bioadhesive/mucoadhesive properties, which in the case of Pluronic-PAA are significant due to the presence of the PAA side chains. An atomic fo...

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (C) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation method...

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (C) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation method...