The developmental signalling protein Notch can be proteolytically activated following ligand-interaction at the cell surface, or can be activated independently of its ligands, following Deltex (Dx)-induced Notch endocytosis and trafficking to the lysosomal membrane. The means by which different pools of Notch are directed towards these alternative outcomes remains poorly understood. We found th...

We prove a natural generalization of Kneser's oscillation criterion and Hardy's inequality for Sturm{Liouville diierential expressions. In particular, assuming ? d dx p 0 (x) d dx + q 0 (x), x 2 (a; b), ?1 a < b 1 to be nonoscillatory near a (or b), we determine conditions on q(x) such that ? d dx p 0 (x) d dx + q 0 (x) + q(x) is nonoscillatory, respectively, oscillatory near a (or b).

1 A lter for edge detection In graylevel images boundaries are often associated to step-like discontinuities. In its simplest form the problem of nding boundaries in 1D images may therefore be thought of as the problem of nding step-discontinuities in a signal. The naive approach to this problem is to use a diierentiator and a threshold in series. The derivative of the signal ought to present l...

The use of pure heavy hydrocarbons like propane or isobutane has some advantages for drift chaders that measure the specific ionisation for particle identification. With a prototype of the ARGUS drift chamber various gases were tested with a 3 GeV/c electron beam. We found a dE/dx resolution for propane of Fwhm= 10.4% and for isobutane Fwhm = 9.9X, by a factor of + 1.6 better than that for argo...

for all #, y in 31 and all a in $. The constants relative to such a derivation are the elements of 3t that commute with d. We shall call an element b a d-integral if b~a for some element a in 31, that is, if the equation x' ~xd—dx*=b has a solution in 31. Clearly if a is a solution of this equation then the totality of solutions is the set {a+c} where c ranges over the set of d-constants. In a ...

Social norms have a pervasive effect on our lives, affecting how and what we eat, how we dress, where and how we travel, our recreation, the way we work, and our participation in the society at large. Other social norms make constraints on the behavior of commercial companies and other institutions, affecting the way they do business, their treatment of employees, their treatment of the environ...

Deinoxanthin (DX) is a unique carotenoid synthesized by Deinococcus radiodurans, one of the most radioresistant organisms known. In comparison with other carotenoids, DX was proven to exhibit significantly stronger reactive oxygen species (ROS)-scavenging activity, which plays an important role in the radioresistance of D. radiodurans. In this work, to gain deeper insights into the strong antio...

The effects of hyperkalemia on serum and myocardial digoxin (DX) concentration was studied in conjunction with hemodynamic changes in 31 normal dogs. The myocardial DX concentration in the hyperkalemic (HK) group was significantly lower than that in normokalemic (NK) group, despite a significantly higher serum DX concentration in the HK group. In the HK group, the myocardial sodium concentratio...

2 D-module fundamentals 4 2.1 DX and DX -modules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.2 Inverse images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.3 Direct images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.4 Tensor products . . . . . . . . . . . . . . . . . . . . . . . . ....

3. (a) Let M be an infinite σ-algebra of subsets of some set X. There exists a countably infinite subcollection C ⊆M, and we may choose C to be closed under taking complements (adding in missing complements if necessary). For each x ∈ X, define Dx := ∩{C ∈ C | x ∈ C}, so that Dx ∈ M. Let x, y ∈ X and suppose y ∈ Dx. Then y ∈ C for all C ∈ C with x ∈ C. Moreover, if y ∈ C for some C ∈ C, then y ...