objective: in recent years, humman papilomaviruses (hpv) infection is the most common type of sexual trasmitted diseases (std) in majority of countries. it's a significant source of morbidity and mortality worldwide. in this study, we aimed to compare the history of reproductive disease between two groups of iranian women with and without hpv infection through colposcopy precedure. materials an...

condyloma acuminatum, is a rare sexually transmitted disease. the virus responsible for condyloma is human papillomavirus. hpv-6 and hpv-11 are the most commonly detected hpv genotypes, but at least 20 other hpv genotypes have occasionally been found in genital wart tissue specimens. in fact genital hpv infection is common among sexually active populations. this disease may occur at any age aft...

The virus-induced papillomas of cottontail as well as domestic rabbits regress completely within a few weeks when exposed to 5,000 r of x-ray irradiation. The x-rays do not immediately kill the papilloma cells, but lead to death by inhibiting cellular division and producing pathological changes in the cells which then continue to differentiate. The virus associated with the growths, however, no...

Cervical cancers transformed by high risk human papilloma virus (HPV) express the E7 oncoprotein, which accelerates the degradation of the retinoblastoma protein (Rb). Here we show that the E7-mediated degradation of Rb requires the calcium-activated cysteine protease, calpain. E7 bound and activated mu-calpain and promoted cleavage at Rb(810), with mutation of this residue preventing E7-mediat...

High prevalence of infection with high-risk human papilloma virus (HPV) ranging from 25 to 100% (average 31%) was observed in breast cancer (BC) patients in Singapore using novel DNA chip technology. Early stage of BC demonstrated higher HPV positivity, and BC positive for estrogen receptor (ER) showed significantly higher HPV infection rate. This unique association of HPV with BC in vivo promp...

Professor Harald zur Hausen, emeritus Scientific Director and Chairman of the Management Board of the German Cancer Research Center in Heidelberg, has made seminal observations that identify novel human papilloma viruses as key contributors to cervical cancer. Cervical cancer is the second most common cancer among women. Professor zur Hausen's discoveries include detection of novel human papill...

Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial T cells being superior to stromal T cells. To assess whether the epithelial T cell biomarker CD103 could specifically discriminate the benefic...

The genetic composition of the E6 and E7 oncogenes is very susceptible to mutation. Mutations occur due interactions between viral genome host. Changes in one nucleotide can affect function these so that they trigger persistence Human Papilloma Virus (HPV) infection cervical cancer progression several intratypic variants HPV type 16 alteration p16 expression cases. This study was conducted on w...

Three tumors initiated by well characterized viruses, but in which virus is not detectable by ordinary virological techniques, are discussed. The question of the possible state of the virus within these seemingly non-infectious tumors is considered, largely from the standpoint of findings with the rabbit papilloma virus. This agent in its natural host, the cottontail rabbit, is infective, can b...

conclusions the results of this meta-analysis showed that gardasil and cervarix vaccines are highly effective against cervical cancer. according to the point that approximately 50% of cervical cancers and human carcinogenicity are related to hpv-16 infection, the bivalent hpv vaccine might have protective effects against hpv-16 cin2-3 lesion and cervical cancer. results by combining the results...