The etiology of pathological jaundice can not be identified in almost half of the cases. The effect of promoter polymorphism in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene was investigated in healthy breast-fed Turkish neonates with unexplained and direct Coombs'-negative ABO incompatible hyperbilirubinemia. Newborns whose peak serum bilirubin levels were > or = 17 mg/dl and < or = 12.9 m...

OBJECTIVE: Neonatal hyperbilirubinemia (N-HB) usually resulted in bilirubin encephalopathy even death in children. The present study was designed to investigate the prevention and intervention initiatives for N-HB. MATERIALS AND METHODS: Case-control method was used to study the effects of early intervention on neonate with hyperbilirubinemia and perinatal factors. A total of 412 N-HB cases (20...

background: maternal and neonatal factors could help determine the potential incidence of hyperbilirubinemia. in this study, we aimed to identify the relationship between the severity of jaundice in newborns and maternal and neonatal factors. methods: this descriptive, cross-sectional study was conducted in 2014. icteric newborns, admitted to qods and kowsar teaching hospitals in qazvin, iran w...

Abstract Thyroid storm (TS) is a rare and life-threatening condition due to profound hypermetabolic state, leading decompensation of homeostasis. It commonly associated with precipitating factor such as surgery, trauma, or infection. Occasionally, the clinical presentation may be non-specific, thus causing potential delay in diagnosis. This could problematic condition’s high mortality rate, esp...

Prolonged neonatal jaundice is defined as a jaundice lasting more than 14 days of life in the full-term infants [1,2]. Etiologically it is helpful to distinguish jaundice related to unconjugated (indirect) or conjugated (direct) hyperbilirubinemia. A prolonged unconjugated hyperbilirubinemia may be related to breastfeeding or to some pathological conditions as hemolytic diseases (due to Rh or A...

Background: Maternal and neonatal factors could help determine the potential incidence of hyperbilirubinemia. In this study, we aimed to identify the relationship between the severity of jaundice in newborns and maternal and neonatal factors. Methods: This descriptive, cross-sectional study was conducted in 2014. Icteric newborns, admitted to Qods and Kowsar teaching hospitals in Qazvin, Iran ...

glucose-6-phosphate dehydrogenase (g6pd) deficiency is the most important disease of the hexose monophosphate pathway. deficiency of this enzym can lead to hemolysis of red blood cells. our aim was to study the prevalence of g6pd deficiency in relation to neonatal jaundice. we studied 456 clinically icteric neonates laboratory investigations included determination of direct and indirect serum b...

BACKGROUND Blood group mismatch between a mother and newborn carries a substantial risk for neonatal hyperbilirubinemia and kernicterus. In the current study, we investigate the spectrum and outcome of marked neonatal hyperbilirubinemia with blood group incompatibility. METHODS We retrospectively assessed a cohort of 413 neonates with peak total serum bilirubin (TSB) values > or = 20 mg/dL be...

OBJECTIVE In the era of early discharge of newborns from the hospital, newborns with ABO incompatibility are at especially greater risk for developing a subsequent significant hyperbilirubinemia because some of these infants also may present with some degree of ABO isoimmune disease. In this study, we aimed to determine prospectively the critical serum total bilirubin level to predict significa...