Traumatic brain injury often leads to epileptic seizures. Among other factors, homeostatic synaptic plasticity (HSP) mediates posttraumatic epileptogenesis through unbalanced synaptic scaling, partially compensating for the trauma-incurred loss of neural excitability. HSP is mediated in part by tumor necrosis factor alpha (TNFα), which is released locally from reactive astrocytes early after tr...

PURPOSE There is an increasing incidence of mortality among trauma patients; therefore, it is important to analyze the trauma epidemiology in order to prevent trauma death. The authors reviewed the trauma epidemiology retrospectively at a regional emergency center of Korea and evaluated the main factors that led to trauma-related deaths. MATERIALS AND METHODS A total of 17007 trauma patients ...

BACKGROUND Adult respiratory distress syndrome is often refractory to treatment and develops after entering the health care system. This suggests an opportunity to prevent this syndrome before it develops. The objective of this study was to demonstrate that early application of airway pressure release ventilation in high-risk trauma patients reduces hospital mortality as compared with similarly...

BACKGROUND Exposure to acute, potentially traumatic events is an unfortunately common experience for children and adolescents. Posttraumatic stress (PTS) responses following acute trauma can have an ongoing impact on child development and well-being. Early intervention to prevent or reduce PTS responses holds promise but requires careful development and empirical evaluation. OBJECTIVES The ai...

by the year 2020, the incidence of trauma has been predicted to rise worldwide and the death rate is expected to increase from 5.1 million to 8.4 million. the most important cause of death and severe morbidity up to the age of 45 years is traumatic brain injury, with or without polytrauma. since the early 1970s, traffic-related deaths in germany have dropped continuously—with the exception of t...

Traumatic tricuspid regurgitation is a rare complication of blunt chest trauma. With the increase in the number of automobile accidents, traumatic tricuspid regurgitation has become an important problem after blunt chest trauma. It has been reported more frequently because of better diagnostic procedures and a better understanding of the pathology. The early diagnosis of traumatic tricuspid reg...

background trauma mostly occurs in young patients. trauma is characterized by a combination of cardiovascular, inflammatory, and metabolic responses. hypercatabolism after trauma may lead to acute protein malnutrition that ultimately results in multiple organ failure. nutritional support may prevent this sequence. therefore, nutritional support is an essential component of the care of critical ...

Fibrinogen is fundamental to hemostasis and falls rapidly in trauma hemorrhage, although levels are not routinely measured in the acute bleeding episode. Prompt identification of critically low levels of fibrinogen and early supplementation has the potential to correct trauma-induced coagulation and improve outcomes. Early estimation of hypofibrinogenemia is possible using surrogate markers of ...

Early hospital management of trauma patients is a daily activity for most emergency physicians. The ability to quickly assess, stabilize and initiate treatment of these patients is critically important to optimize outcomes. This issue of “Resident Journal Review” focuses on selected updates in the trauma literature. We specifically review new developments in trauma pharmacology, biomarkers in t...