Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicidal and are somehow resurrected elsewhere in the genome. After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key realizations that (A) DNA site-dependent regulation is broadly conserved and (B) i...

In the northeastern United States, pitch pine ( Pinus rigida Mill.)–scrub oak (Quercus ilicifolia Wang.) communities are increasingly threatened by development and fire suppression, and prioritization of these habitats for conservation is of critical importance. As a basis for local conservation planning in a pitch pine–scrub oak community in southeastern Massachusetts, we developed logistic-re...

Most recombination takes place in numerous, localized regions called hotspots. However, empirical evidence indicates that nascent hotspots are susceptible to removal due to biased gene conversion, so it is paradoxical that they should be so widespread. Previous modeling work has shown that hotspots can evolve due to genetic drift overpowering their intrinsic disadvantage. Here we synthesize rec...

Crime tends to cluster geographically. This has led to the wide usage of hotspot analysis to identify and visualize crime. Accurately identified crime hotspots can greatly benefit the public by creating accurate threat visualizations, more efficiently allocating police resources, and predicting crime. Yet existing mapping methods usually identify hotspots without considering the underlying corr...

Hotspots of high species diversity are a prominent feature of modern global biodiversity patterns. Fossil and molecular evidence is starting to reveal the history of these hotspots. There have been at least three marine biodiversity hotspots during the past 50 million years. They have moved across almost half the globe, with their timing and locations coinciding with major tectonic events. The ...

On 12 May 2008, the 8.0-magnitude Wenchuan earthquake occurred in Sichuan Province, China, triggering thousands of landslides, debris flows, and barrier lakes, leading to a substantial loss of life and damage to the local environment and infrastructure. This study aimed to monitor the status of geologic hazards and vegetation recovery in a post-earthquake disaster area using high-resolution aer...

Earthquake clustering phenomena such as aftershocks, foreshocks, and pairing of mainshocks are prominent and characteristic features of earthquake occurrence. Because the earthquake nucleation process controls the time and place of occurrence of earthquakes, non-linear dependence of nucleation times on stress changes can strongly affect the spatial and temporal patterns of earthquake occurrence...

Trauma experience not only could predict longterm physical and mental health problems, but also could have impact on the cognitive processes. Modified Stroop task and subliminal masked priming task were used to examine the automatic cognitive processing of earthquake-related stimulus (disaster-related, rescue-related, and earthquake-unrelated words) of healthy undergraduates at one month and tw...

PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of PRDM9 regulation, in terms of motifs defined and hotspots studied, has a strong bias toward the PRDM9 A variant particularly common in Europeans. We show that population diversity can reveal a second class...

Animal-derived nutrients play an important role in structuring nutrient regimes within and between ecosystems. When animals undergo repetitive, aggregating behavior through time, they can create nutrient hotspots where rates of biogeochemical activity are higher than those found in the surrounding environment. In turn, these hotspots can influence ecosystem processes and community structure. We...