combination formulations of liposomes with collagen have been previously introduced as a means of obtaining more stable and less permeable liposomes. in this study, the effect of aqueous solutions of the collagen products collapur? (col) and collapuron-dak? (cold) from henkle co., on the release rate of sodium chromate (chr) as a water-soluble model drug from stable plurilamellar vesicles (splv...

DESCRIPTION An ex-preterm infant collapsed acutelywith abdominal distension, bradycardia and desaturation. Urgent echocardiogram to exclude pericardial tamponade revealed multiple, highly echogenic, foci in all four, but particularly the rightsided, cardiac chambers (video 1). Cranial ultrasound revealed multiple echogenic foci throughout the cerebral arterial vasculature, following paths of th...

Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...

We assessed whether echogenic needles reduce tip location error, by comparing three echogenic designs (Pajunk Sonoplex, Lifetech, B. Braun Stimuplex D+) with a non-echogenic control (Pajunk Uniplex), using a novel assessment technique in unembalmed human cadavers. Multiple images were taken of each needle at shallow (15 to 25 degrees), moderate (35 to 45 degrees) and steep (55 to 65 degrees) in...

The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...

early detection of free air in the peritoneal cavity is vital in diagnosis of life-threatening emergencies, and can play a significant role in expediting treatment. we present a series of cases in which bedside ultrasound (us) in the emergency department accurately identified evidence of free intra-peritoneal air and echogenic (dirty) free fluid consistent with a surgical final diagnosis of a p...

In order to obtain antineoplastic compounds and innovative formulations, new technologies testing methods are continuously being developed. Unfortunately, besides cancer cells, chemotherapy also affects normal cells. An option avoid toxicity is represented by the targeted treatment using novel pharmaceutical dosage forms.
 Liposomes represent a relatively form, used for their many advantag...

Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...

The presence of heparin in a biological environment affects the cellular uptake extent positively charged liposomes but not negatively liposomes.