نتایج جستجو برای: edss
تعداد نتایج: 1456 فیلتر نتایج به سال:
• As described in more detail in Ruutiainen et al. (2015), 553 Finnish persons with MS (PwMS) drawn from the membership register of the national patient society completed a postal survey, which aimed at determining the economic and health-related quality of life (HRQoL) burden of MS in Finland. • Survey questionnaire included self-administered EDSS and MSIS-29. EDSS score ranges from 0 to 9 and...
Probing the cortic ospinal tract integrity by transcranial magnetic stimulation (TMS) could help to understand neurophysiological correlations of multiple sclerosis (MS) symptoms. Therefore, study objective was, first, investigate TMS measures (resting motor threshold-RMT, evoked potential (MEP) latency, and amplitude) corticospinal in people with relapsing-remitting MS (pwMS). Then, examined c...
Introduction: The purpose of the study is to investigate correlation between the expanded disability status scale, depression, quality of life (QoL) and age as well as to investigate the impact of the interferon beta-1b in the QoL of MS patients and its possible depressogenic effect. Material and methods: This prospective study included 70 randomly selected patients with MS treated in the clini...
BACKGROUND There is a known inverse association between solar radiation and the prevalence of multiple sclerosis (MS). Some studies have investigated the link between vitamin D and MS. The aim of this study was to investigate the possible association between serum 25(OH) vitamin D3 concentration and the severity of disease in Iranian patients with MS. METHODS Patients with relapsing-remitting...
Ectodermal dysplasias form a large disease family with more than 200 members. The combination of hair and tooth abnormalities, alopecia, and cutaneous syndactyly is characteristic of ectodermal dysplasia-syndactyly syndrome (EDSS). We used a homozygosity mapping approach to map the EDSS locus to 1q23 in a consanguineous Algerian family. By candidate gene analysis, we identified a homozygous mut...
Multiple Sclerosis (MS) is a disease which affects the central nervous system and causes balance problem. In clinical, this disorder is usually evaluated using static posturography. Some linear or nonlinear measures, extracted from the posturographic data (i.e. center of pressure, COP) recorded during a balance test, has been used to analyze postural control of MS patients. In this study, the t...
BACKGROUND The ability to better predict disease progression represents a major unmet need in multiple sclerosis (MS), and would help to inform therapeutic and management choices. OBJECTIVES To develop multilevel models using longitudinal data on disease progression in patients with relapsing-remitting MS (RRMS) or secondary-progressive MS (SPMS); and to use these models to estimate the assoc...
Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT(-/-)) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. Th...
BACKGROUND Magnetization transfer (MT) magnetic resonance imaging (MRI) can provide in vivo quantitative estimates of microscopic tissue damage in normal-appearing white matter (NAWM) and gray matter (GM) from patients with multiple sclerosis (MS). OBJECTIVE To determine whether a one-time MT MRI can provide markers of short-term disease evolution in patients with relapsing-remitting MS. DE...
Fingolimod approval was based mainly on two clinical trials, FREEDOMS and TRANSFORMS, which demonstrated the efficacy and safety of fingolimod in patients with multiple sclerosis (MS). We present an observational study that validates these trials findings in a real-world setting, whereby the effectiveness and safety of fingolimod was assessed in Seville's' (Spain) clinical practice. This retros...
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