Cathepsin D has been purified approximately 900-fold from two types of cartilage: elastic cartilage of young rabbit ears and hyaline cartilage from the legs of 12to 13-day-old chick embryos. Cathepsin D accounts for most of the hemoglobin-digesting activity of chick cartilage; rabbit ear cartilage also contains a sulfhydryl-dependent acid cathepsin. The identification of the acid proteolytic ac...

The progression of osteoarthritis can be accompanied by depth-dependent changes in the properties of articular cartilage. The objective of the present study was to determine the subsequent alteration in the fluid pressurization in the human knee using a three-dimensional computer model. Only a small compression in the femur-tibia direction was applied to avoid numerical difficulties. The materi...

The distribution oftype II collagen, considered to be characteristic ofcartilaginous tissues, was determined in various specialized cartilages of the mature pig. The tissues examined were: (1) fibrocartilage of the semilunar meniscus of the knee; (2) elastic cartilage of the external ear; (3) hyaline cartilage of (a) the synoviral joint, (b) the thyroid plate of the larynx, and (c) the nasal se...

OBJECTIVE To determine how mechanical stability changes in the lower lateral cartilage (LLC) after varying degrees of cephalic resection in a porcine cartilage nasal tip model. METHODS Alar cartilage was harvested from fresh porcine crania (n = 14) and sectioned to precisely emulate a human LLC in size and dimension. Flexural mechanical analysis was performed both before and after cephalic tr...

*Lu, XL; *Guo, XE; +*Mow, VC +*Department of Biomedical Engineering, Columbia University, New York, NY [email protected] INTRODUCTION The triphasic mixture theories for articular cartilage [1] have been successfully used to describe the flow-dependent and flow-independent viscoelastic behaviors, swelling behaviors, and electrokinetic behaviors of charged-hydrated soft tissues in the last two d...

Nerve growth factor (NGF) exerts its action through two types of receptor: high-affinity tyrosine kinase A receptor (trkA) and low-affinity p75 receptor. NGF has a neurotrophic role in central and peripheral nervous system development, but there is also clear evidence of its involvement in the developing skeleton. The aim of the present immunohistochemical study was to investigate the expressio...

The pathology of "nasal tip complex" remains as a problem to be solved in unilateral cleft lip nose deformity wherein open rhinoplasty and cartilage grafts are used frequently. For this reason, the research for the treatment of cleft-side tip projection lost and ala depression still continues. Our technique is to put the cartilage graft at posterior dome area after the release of cleft-side ala...

There is little or no information about the distribution of elastic fibers in the human fetal head. We examined this issue in 15 late-stage fetuses (crown-rump length, 220-320 mm) using aldehyde-fuchsin and elastica-Masson staining, and we used the arterial wall elastic laminae and external ear cartilages as positive staining controls. The posterior pharyngeal wall, as well as the ligaments con...

Small ruminants are very important in securing food security and economically significant the rural community especially west African country. The larynx serves as both airway passage organ of vocalization, which associated with their own pathology diseases. In current study, 9 specimens larynxes from apparently healthy red sokoto goats were obtained Sokoto Modern abattoir, dissected, morpholog...

A cartilage growth mixture (CGM) model is linearized for infinitesimal elastic and growth strains. Parametric studies for equilibrium and nonequilibrium boundary-value problems representing the in vitro growth of cylindrical cartilage constructs are solved. The results show that the CGM model is capable of describing the main biomechanical features of cartilage growth. The solutions to the equi...