Gentiopicroside (Gent) is promising as an important protective secoiridoid compound against pain. The present study was designed to investigate whether administration of Gent would alleviate the expression of nociceptive behaviors and whether it would cause the relevant electrophysiological changes in a chronic constriction injury (CCI) model of neuropathic pain in mice. Gent was administered f...

Although recovery from spinal cord injury is generally meager, evidence suggests that step training can improve stepping performance, particularly after neonatal spinal injury. The location and nature of the changes in neural substrates underlying the behavioral improvements are not well understood. We examined the kinematics of stepping performance and cellular and synaptic electrophysiologica...

objective: it is well known that intracerebroventricular (icv) and supraspinal injections of orexin-a elicit analgesia, but the mechanism(s) of action remains unidentified. this study aims to characterize the effect of orexin-a on rostral ventromedial medulla (rvm) neurons which are involved in the descending nociception modulating pathway. materials and methods: in this experimental study, we ...

Non-invasive functional activation of denervated muscles and assessment of muscle function require novel stimulation and measurement techniques. Stimulation equipment must be safe enough for home-based training though the applied electrical parameters raise critical safety issues. Assessment of biomechanical and electrophysiological parameters is provided by oscillation tonometry, twitch and m-...

Background/aim: This study aimed to compare the effectiveness of ultrasound (US)-guided injection versus blind injection of corticosteroids in the treatment of carpal tunnel syndrome (CTS). Materials and methods: This prospective, randomized clinical trial included patients with severe CTS based on clinical and electrophysiological criteria. The patients were evaluated for clinical and electrop...

Atrial fibrillation (AF) as a severe arrhythmia is now spreading worldwide at overwhelmingly high rates, particularly in elderly patients. Despite new insights, the mechanisms underlying AF are not conclusively determined yet. Taking into account the ischemic origin of arrhythmia induction (according to the so-called conflictogenic atrial fibrillation, declared recently) restoration of regional...

Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. We performed a systematic search of the literature focused on visual electrophysiology studies, including electroretinography (ERG), electrooculography (EOG), and visual evoked potenti...