Abstract Background Female-limited early-onset high myopia, also called Myopia-26 is a rare monogenic disorder characterized by severe short sightedness starting in early childhood and progressing to blindness potentially the middle ages. Despite X-linked locus of mutated ARR3 gene, disease paradoxically affects females only, with males being asymptomatic carriers. Previously, this has only bee...

Human vision comprises different structures whose physiological functions act as variable for a healthy human vision. Retina plays vital role in vision, hosting cells and neuron ten layers. The perikaryal of these neurons are segregated from neurological processes, forming discrete layers1. inner retina includes ganglion amacrine cells, whereas the outer rod cone photoreceptors. primary photore...

PURPOSE To report changes in the tapetal-like reflex in a female carrier of RPGR ORF15 c.3395delA X-linked retinitis pigmentosa (XLRP) between examinations at 16 and 22 years of age, and to report the observation that the tapetal-like reflex faded due to exposure to daylight and reappeared with prolonged dark adaptation at 22 years of age. METHODS Clinical examination, kinetic Goldmann perime...

We measured electroretinograms (ERGs) for the isolated short-wavelength-sensitive (SWS) cones using a substitution technique. The stimulus was a 5 Hz alternation of 460 nm and 565 nm or 490 nm and 565 nm light of equivalent photopic luminous efficiency. We used a 571 nm narrow-band adaptation field of 7000 td to improve SWS cone isolation and to suppress rod activity. The resulting SWS cone ERG...

The aim was to investigate the proteolytic activity of plasmin and its long-term complications. Plasmin was injected into the vitreous cavity of rabbits' eyes. Slit lamp biomicroscopy and electroretinography were performed. Rabbits were serially sacrificed at four months, and globes fixated and prepared for light and transmission electron microscopy. In both the plasmin-injected and control eye...