INTRODUCTION Pharmaceutical industry is no longer allowed to develop new medicines for use in adults only, as the 2007 Paediatric Regulation requires children to be considered also. The plans for such paediatric development called Paediatric Investigation Plans (PIPs) are subject to agreement by the European Medicines Agency (EMA) and its Paediatric Committee (PDCO). The aim of this study was t...

challenging in general, not only for children’s cancers,” says Chesler. “To encourage commercial development, the EMA should consider creative and more robust ways of working with pharma, academia, and government to make the PIP scheme more effi cient.” The FDA and the EMA already share information and communicate regularly about promising drugs, says Reaman. “It’s possible for the FDA and the ...

Background: Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. Aims: To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. Patients:...

BACKGROUND The use of mHealth methods for capturing illicit drug use and associated behaviors have become more widely used in research settings, yet there is little research as to how valid these methods are compared to known measures of capturing and quantifying drug use. OBJECTIVE We examined the concordance of ecological momentary assessment (EMA) of drug use to previously validated biolog...

OBJECTIVE To examine the seroprevalence, correlates, and characteristics of undetected coeliac disease in a large adult population sample in Cambridge, UK. METHODS The Cambridge General Practice Health Study invited individuals from 12 general practices, aged 45-76 years, to attend for a health survey that included a bone density measurement, between 1990 and 1995. A total of 7550 participant...

Context: Stroke has several consequences on survivors' daily life even for those who experience short-lasting neurological symptoms with no functional disability. Depression and anxiety are common psychological disorders occurring after a stroke. They affect long-term outcomes and quality of life but they are difficult to diagnose because of the neurobiological consequences of brain lesions. Cu...

Nocker and Camper reported that DNA from dead bacterial cells (Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium) treated with ethidium monoazide (EMA) is lost during the DNA extraction procedure (2). This was concluded from the missing or less intense DNA band on an agarose gel stained with ethidium bromide in comparison to the intensities of bands in untreated samples. Acco...

this paper proposes the exchange market algorithm (ema) to solve the combined economic and emission dispatch (ceed) problems in thermal power plants. the ema is a new, robust and efficient algorithm to exploit the global optimum point in optimization problems. existence of two seeking operators in ema provides a high ability in exploiting global optimum point. in order to show the capabilities ...

As the aviation industry evolves toward nextgeneration fly-by-wire vehicles, hydraulic and electrohydrostatic actuators (EHA) are replaced with their electro-mechanical counterparts. By eliminating fluid leakage problems while reducing weight and enhancing vehicle control, the feasibility of electromechanical actuators (EMA) in avionic applications has been established. However, due to the inhe...

0957-4158/$ see front matter 2010 Elsevier Ltd. A doi:10.1016/j.mechatronics.2010.09.001 ⇑ Corresponding author. ⇑⇑ Corresponding author. E-mail addresses: [email protected] (J. Park), spark@jn Various electromagnetic based actuation (EMA) methods have been proposed for the actuation of microrobots. The advantage of EMA is that it can generate a wireless driving force for the microrobot, and this i...