felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to bcs class ii category. hence, its low water solubility limits the pharmacological effect. the aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

Ru/Al2O3 nano-catalysts were prepared with impregnation and microemulsion techniques. The supercritical water gasification reaction was performed at 400oC and 5-60 min. Within the tested operation conditions, the reaction residence time of 15 min was the optimum to maximize the H2 yield. It was observed that using microemulsion technique increases the total gas yield significantly. Using microe...

The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

The biodegradable cellular capsule, being prepared from simple vaporization of liquid marbles, is an ideal vehicle for the potential application of drug encapsulation and release. This paper reports the fabrication of cellular capsules via facile vaporization of Pickering emulsion marbles in an ambient atmosphere. Stable Pickering emulsion (water in oil) was prepared while utilizing dichloromet...

BACKGROUND AND PURPOSE Clinical cerebral-fat embolism shows both reversible and irreversible changes. We used MR imaging to investigate the reversibility of embolized lesions induced with a fat-emulsion technique and to evaluate the histologic findings. METHODS A fat emulsion was made with 0.05 mL of triolein and 20 mL of normal saline and vigorous to-and-fro movement through a three-way stop...

The hydrodynamics, viz. the solids circulation patterns and bubble behavior, of a freely bubbling gas-solid fluidized bed has been investigated experimentally using Particle Image Velocimetry (PIV) combined with Digital Image Analysis (DIA). Coupling of these non-invasive measuring techniques allows us to obtain information on both the bubble behavior and emulsion phase circulation patterns sim...

Biodegradable gadopentetic acid (Gd-DTPA)-loaded chitosan microparticles (Gd-microCPs) were prepared as a device for gadolinium neutron-capture therapy (Gd-NCT) by a novel emulsion-droplet coalescence technique: a water-in-oil (w/o) emulsion A containing chitosan and Gd-DTPA in droplets and a w/o emulsion B containing NaOH in droplets were mixed and stirred to solidify chitosan as a result of c...

Localized delivery of nucleic acids to target sites (e.g., diseased tissue) is critical for safe and efficacious gene therapy. An ultrasound-based technique termed acoustic droplet vaporization (ADV) has been used to spatiotemporally control the release of therapeutic small molecules and proteins contained within sonosensitive emulsions. Here, ADV is used to control the release of lipoplex-cont...