amelogenesis imperfecta (ai) is a disorder of tooth development where there is an abnormal formation of enamel or the external layer of teeth. the aim of this study was to screen mutations in the four most important candidate genes, enam, klk4, mmp20 and fam83h responsible for amelogenesis imperfect.geneomic dna was isolated from five iranian families with 22 members affected with enamel malfor...

background: amelogenesis imperfecta (ai) is an inherited tooth disorder. despite the fact that up to now, several gene muta­tions in mmp20, enam, amelx and klk4 genes have been reported to be associated with ai, many other genes sug­gested to be involved. the main objective of this study was to find the mutations in three major candidate genes including mmp20, enam and klk4 responsible for ai f...

l i s e l t p a r a n d a d a , s e a l h u l g a s l i s a d e s r e s s u r s s e t e g e v us t e l e , Eesti peab infoühiskonna arendamiseks senisest enam väärtustama infotehnoloogiaga tegelevaid inimesi, tagama valdkonna stabiilsema rahastamise, soodustama infotehnoloogiat sisaldavate eluvaldkondade projektide elluviimist ning edendama teadustööks vajalikku infrastruktuuri. m i s a i t a v...

Amelogenesis imperfecta (AI) is a genetically heterogeneous group of diseases that result in defective development of tooth enamel. Mutations in several enamel proteins and proteinases have been associated with AI. The object of this study was to evaluate evidence of etiology for the six major candidate gene loci in two Brazilian families with AI. Genomic DNA was obtained from family members an...