Over a quarter of a century ago, Mykles described the presence of putative endocrine cells in the midgut epithelium of the crab Cancer magister (Mykles, 1979). In the years that have followed, these cells have been largely ignored and nothing is known about their hormone content or the functions they play in this species. Here, we used a combination of immunohistochemistry and mass spectrometri...

The orphan receptor estrogen-related receptor a (ERRa) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. This protein is structurally most related to the canonical estrogen receptor and has been shown to modulate estrogen signaling in some contexts. These observations have heightened interest in ERRa as a therapeutic target in both breast and ovarian can...

The purpose of this prospective study is to investigate the impact of endocrine treatment persistence on the survival of patients with estrogen receptor-positive breast cancer treated with endocrine therapy and identify the risk factors influencing the treatment persistence. We enrolled 1085 patients from Northeast China who were diagnosed as stage I-III, estrogen receptor-positive breast cance...

PURPOSE Endocrine therapy, using tamoxifen or an aromatase inhibitor, remains first-line therapy for the management of estrogen receptor (ESR1)-positive breast cancer. However, ESR1 mutations or other ligand-independent ESR1 activation mechanisms limit the duration of response. The clinical efficacy of fulvestrant, a selective estrogen receptor downregulator (SERD) that competitively inhibits a...

conclusions the findings of this review showed that many factors can influence the body image of women suffering from breast cancer. these factors were predictors of patients’ inter-personal and intra-personal relationships with their partners and others who influenced various other aspects of their lives, possibly leading to many life’s issues. these factors must be identified and considered t...

thyroid cancer is the most common endocrine malignancy. this study surveys the pathologic characteristics of thyroid cancerin mashhad and study of papillary carcinoma in more detail. in this retrospective study, 108 out of 197 cases of thyroid cancer were papillary in type (55%), with female to male ratio of 1.91 which is lower than current reports. the age at the time of diagnosis ranged from ...

Endocrine-disrupting chemicals (EDCs) are exogenous that interfere with hormones action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature mechanistic studies provides evidence on hazards EDC exposure, yet there is no widely accepted systematic method to integrate these data help identify hazar...

Brain metastasis (BM) in breast cancer is a devastating condition, yet little known about features unique to the brain environment. When develops ER-positive cancer, endocrine therapy can still work as main treatment. Several pieces of research have concluded on estrogen effect and activity toward BM. The purpose this study was find prognostic factors treatment strategies that could extend brai...

BACKGROUND Several studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression. METHODS This randomised trial included men from 47 centres in Norway, Sweden, and Denma...