Background Determination of the role of steroid hormones in expression and regulation of endometrial glucose transport 4 (GLUT4) in humans is important for understanding endometrial disorders such as polycystic ovary syndrome (PCOS), a common hormone-imbalance disease. Methods Endometrial biopsy samples were collected from non-PCOS patients with regular menstrual cycles or with hyperplasia and ...

The nature of endometrial glycoconjugates throughout the menstrual cycle was investigated using a panel of lectins directed against specific sugar groups. This approach was also applied to a series of endometrial adenocarcinomas the findings for which were compared with those of normal controls. A change in the expression of glycosubstances was found in relation to the phase of the menstrual cy...

In this study, we investigated the role of FK506 binding protein 51 (FKBP51) in human endometrial adenocarcinoma progression. Immunohistochemical analysis showed decreased FKBP51 expression in endometrial adenocarcinoma tissues. Moreover, higher FKBP51 expression was observed in the normal secretory phase than in proliferative-phase endometrial tissues. FKBP51-shRNA transfected KLE cells showed...

In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit and differentiation into decidual cells that control embryo implantation. Here we show that FOXO1 also causes acute senesc...

The study involved ten patients with tubal factor infertility. Patients (Group I, age 28–34 years, n=5; Group II, age 35 – 40 years, n=5) underwent endometrial biopsy on postovulatory days 7–10 of the natural menstrual cycle. Endometrial biopsies were studied by histological methods, presence of trophinin and integrin β3 in the endometrial surface epithelium and in the glandular epithelium was ...

The adult human endometrium rapidly cycles through stages of cell proliferation, differentiation and degeneration. Inappropriate endometrial cell differentiation is a contributing factor in diseases such as endometrial carcinoma and endometriosis. We have identified two homeobox genes that may play a role in the control of endometrial cell differentiation and development. In-situ mRNA hybridiza...

SYNOPSIS The observation by Todd (1964) of a diffuse fibrinolytic activity related to the human endometrium in its secretory stage initiated a reinvestigation of the development of fibrinolytic activity in the uterus and vagina of the rat using the histochemical fibrin slide technique. In addition to the plasminogen activator known to be related to uterine vessels, in the rat in particular to m...

The observation by Todd (1964) of a diffuse fibrinolytic activity related to the human endometrium in its secretory stage initiated a reinvestigation of the development of fibrinolytic activity in the uterus and vagina of the rat using the histochemical fibrin slide technique. In addition to the plasminogen activator known to be related to uterine vessels, in the rat in particular to myometrial...

Endometrium is the inner lining of the uterus which is composed of epithelial and stromal tissue compartments enclosed by the two smooth muscle layers of the myometrium. In women, much of the endometrium is shed and regenerated each month during the menstrual cycle. Endometrial regeneration also occurs after parturition. The cellular mechanisms that regulate endometrial regeneration are still p...

BACKGROUND Ethical constraints limit the ability to study peri-implantation phase human endometrium. In this study, the donor oocyte model was used to study candidate endometrial markers of uterine receptivity. METHODS Archived, paraffin-embedded tissue obtained by endometrial biopsy during cycle days 21-23 of patients undergoing 'mock' hormonal treatment cycles were evaluated by standard his...