BACKGROUND Elevated serum progesterone levels at the end of the follicular phase in controlled ovarian stimulation (COS) leads to a poorer ongoing pregnancy rate in IVF cycles due to reduced endometrial receptivity. The objective of this study was to use microarray technology to compare endometrial gene expression profiles at the window of implantation according to the levels of circulating pro...

Prokineticin 1 (PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates the expression of several genes with important roles in endometrial receptivity and implantation. This study investigated PROK1 regulation of Dickkopf 1 (DKK1) expression, a negative regulator of canonical Wnt signalling, and its function in the non-pregnant endometrium and first trimester decidua. DKK1 mRNA expres...

Aim: Angiogenesis is an essential prerequisite for endometrial development and differentiation. Absence of optimum endometrial perfusion can be one of the important reasons behind the patients with unexplained infertility. The present study was undertaken to identify the endometrial vascularity by Doppler and find its relation with serum VEGF in infertile women. Materials And Methods: 60 Patien...

OBJECTIVE The study was planned to investigate whether DHEA supplementation had an impact on endometrial receptivity in women who were poor responders (POR). MATERIAL AND METHODS Twenty-eight POR women who were undergoing hysteroscopy and five fertile control subjects were included. The POR women were equally subdivided into two separate groups as patients who were currently using DHEA and th...

BACKGROUND Poor endometrial quality is associated with more than a third of embryo implantation failures. Current ultrasonography technology lacks the capacity to determine efficiently the endometrial receptivity during ongoing cycle transfers. We analyzed the relationship between the gene expression profile associated with implantation and clinical pregnancy from endometrial cells taken during...

BACKGROUND Endometrial receptivity is required for successful implantation and pregnancy. Despite the remaining controversy, many studies have shown that ultrasonographic endometrial thickness can be considered as an indicator of endometrial receptivity. OBJECTIVE The study objective was to investigate the effect of dilatation and curettage on the endometrial thickness. MATERIALS AND METHOD...

BACKGROUND Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity. OBJECTIVE The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), interferon gamma-induced protein 10 (IP-10), and mon...

Concepts of implantation physiology developed on the basis of previous work postulate that embryo implantation is initiated when trophoblast invasiveness coincides with astate of 'receptivity' of the endometrium, the latter being controlled by steroid hormones. However, neither trophoblast invasiveness nor endometrial receptivity are well understood in terms of their cell biological basis: a ro...

In cattle, the majority of pregnancy loss can be attributed to early embryonic loss which occurs prior maternal recognition of pregnancy on Day 16 (Day 0 = ovulation). During this time, carefully orchestrated spatio-temporal alterations in the transcriptomic profile of the endometrium are required to drive conceptus elongation, via secretions from the endometrium (termed histotroph) and establi...

BACKGROUND At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA (miRNA) signatures for impaired endometrial receptivity by microarray analysis. METHODS A total of 12 repeated implantation failure (RIF) patients and 10 infertile patients, w...