We previously isolated side-population (SP) cells from a human endometrial cancer cell line, Hec1, and determined that Hec1-SP cells have cancer stem-like cell features. In this study, we isolated SP cells and non-SP (NSP) cells derived from a rat endometrial cell line expressing human [(12)Val] KRAS (RK12V cells) and determined the SP phenotype. RK12V-SP cells showed self-renewal capacity, the...

First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in re...

Background: Endometrial carcinoma develops through preliminary stages of endometrial hyperplasia. A population epithelial stem cells was identified in the human endometrium, these may serve as a source putative carcinoma. The most important member cancer cell markers is OCT-4. Both tumor proliferation (Ki-67) and angiogenesis seem to be for development aggressive tumors. Aim Work: This study ai...

Abstract Study question How to find endometrial epithelial stem cell (eeSC) in the human gland? Summary answer Endometrial organoid culture model combined with omics techniques can be a promising platform for investigating eeSC functions and gland development. What is known already stem/progenitor cells are thought involved regeneration, stromal having been extensively studied. On other hand, s...

Endometriosis is a common gynecological disease. It is unique to have benign histology but with malignant characteristics. Easy recurrence, multiple organ involvement and malignant transformation potential make endometriosis a complex disease. Multi-factors contribute to the pathophysiology. Recently, endometriosis has been regarded as a stem cell disease (Sasson & Taylor, 2008). Some studies h...

We previously isolated side-population (SP) cells from a human endometrial cancer cell line, Hec1, and determined that Hec1-SP cells have cancer stem–like cell features. In this study, we isolated SP cells and nonSP (NSP) cells derived from a rat endometrial cell line expressing human [Val] KRAS (RK12V cells) and determined the SP phenotype. RK12V-SP cells showed self-renewal capacity, the pote...

Human endometrial tissue has become an attractive source of mesenchymal stem cells (MSCs) for cell-based therapies because these MSCs can be easily harvested and have tumour tropism as well as reduced immunogenic and inflammatory properties. Our study aimed to obtain and characterise human endometrial mesenchymal stem cells (EMSCs) and assess their endometriosis tropism. EMSCs were successfully...

The article deals with the physiology of endometrial regeneration after its desquamation phase during menstrual cycle in women, as well an overview studies mesenchymal/stem cells main source tissue regeneration. processes that take place first their physiological essence are repair and regeneration, contrast to proliferation, which is based on regenerative neoplasm tissues, can be observed vari...