In a previous study, we found that intracerebral administration of excitotoxin (RS)-(tetrazole-5yl) glycine caused increased neural damage in the brain in an endothelial COX-2 deleted mouse line (Tie2Cre COX-2(flox/flox) ). In this study, we investigated whether prostacyclin might mediate this endothelial COX-2-dependent neuroprotection. Administration of excitotoxin into the striatum induced t...

Atherosclerosis is the most common cause of cardiovascular diseases worldwide. The endothelial cell apoptosis elicited by oxidized low-density lipoprotein (ox-LDL), which contributes to endothelial damage and inflammation, is a particularly important event in the early stage of atherosclerosis. However, the mechanism underlying ox-LDL-induced endothelial cell apoptosis remains unclear. Here we ...

SARS-CoV-2 was firstly found in bronchoalveloar lavage (BAL) of three suspected COVID-19 patients at Jinyintan Hospital, Wuhan, Hubei Province, China. The cases are still raisingwith2,12% global mortality rate. Hypoxic respiratory failure due to acute distress syndrome (ARDS) is the main cause death. Endothelial cell damage has an important role pathogenesis ARDS and multi-organ dysfuntion pati...