Abstract The rapid reversal of splenomegaly in Epstein Barr Virus EBV infected children and young adults was seen in over 50 patients treated with a combination therapy that reduced reactive oxygen species, increased interferon gamma and decreased free nitric oxide in lymphocytes. The patients showed dramatic improvement within 24 hours with successful remission of the disease and complete reve...

Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.

BACKGROUND Diabetic heart disease is associated with tetrahydrobiopterin oxidation and high arginase activity, leading to endothelial nitric oxide synthase dysfunction. Sepiapterin (SEP) is a tetrahydrobiopterin precursor, and L-citrulline (L-Cit) is converted to endothelial nitric oxide synthase substrate, L-arginine. Whether SEP and L-Cit are effective at reducing diabetic heart disease is no...

The last few decades have witnessed an increased life expectancy of patients suffering with systemic rheumatic diseases, mainly due to improved management, advanced therapies and preventative measures. However, autoimmune disorders are associated with significantly enhanced cardiovascular morbidity and mortality not fully explained by traditional cardiovascular disease (CVD) risk factors. It ha...

background: skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. in a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on tissue survival in a rat model of skin flap grafting. in the current study, we investigated the involvement of nitric oxide and inducible nitric o...

improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol 2002;39:754–9. 4. Akasaki Y, Miyata M, Eto H, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 2006:70;463–70. 5. Aicher A, Heeschen C, Mildner-Rihm C, et al. Essential role of endotheli...

Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. Genetic predisposition, metabolic disorders and other effects, including occupational hazards, can lead to formation endothelial dysfunction. The study aims assess polymorphisms candidate genes development diseases persons with pathology. Scientists have found that carriage certain alleles G894T nitr...

Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibition of small G-proteins Rho and Rac. Rho negatively regulates endothelial nitri...

Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibition of small G-proteins Rho and Rac. Rho negatively regulates endothelial nitri...

Endothelial dysfunction, with impaired bioavailability and/or bioactivity of the vasoprotective molecule, nitric oxide, appears to be a vital step in initiation atherosclerosis. Several studies have shown that dietary nitrate/nitrite can significant benefits on human cardiovascular homeostasis. Although serum nitrite concentrations reach micromolar levels, physiological significance normal tiss...