Multidrug resistance (MDR), a common cause of chemotherapeutic failure, is associated with the expression of P-glycoprotein (P-gp), encoded for by ABCB1, the multidrug resistance gene. Our purpose was to determine whether ABCB1 expression is expressed after exposure of two canine lymphoid cell lines to prednisolone or enrofloxacin. Two established lymphoid cell lines (GL-1, 17-71) were cultured...

The purpose of the present study was to establish a pharmacokinetic/pharmacodynamic (PK/PD) modeling approach for the dosage schedule design and decreasing the emergence of drug-resistant bacteria. The minimal inhibitory concentration (MIC) of 929 Escherichia coli isolates from broilers to enrofloxacin and ciprofloxacin was determined following CLSI guidance. The MIC50 was calculated as the pop...

The pharmacokinetics and bioavailability of enrofloxacin was compared in Cobb strain broiler chicken after intravenous and oral administration of enrofloxacin at the rate of 10mg.kg -1 . The concentration of enrofloxacin at various time intervals in plasma was determined by HPLC and the pharmacokinetic parameters were calculated by non compartmental approach. AUC was significantly high in i.v. ...

Contamination of food producing animals by veterinary drug residues, particularly quinolones, is an essential issue in food safety that causes increasing concern in consumers. The aim of this study was to investigate the occurrence of enrofloxacin and its main metabolite, ciprofloxacin, in chicken tissue samples slaughtered in Tabriz, Iran. Totally 250 samples including liver, muscle, gizzard, ...

Aim: Evaluation of meloxicam, levofloxacin, pazufloxacin, and enrofloxacin for their effect on the plasma antioxidative activity (AOA) and the body weight in rabbits. Materials and Methods: Thirty two male Soviet Chinchilla rabbits were divided to eight groups of four rabbits each. Group A, serving as control, was administered 5 % dextrose. Group B, C, E and G were gavaged meloxicam, levofloxac...

The aim of this study was to optimize the dose regimens of enrofloxacin to reduce the development of fluoroquinolone resistance in Escherichia coli (E.coli) using pharmacokinetic/pharmacodynamic (PK/PD) modeling approach. The single dose (2.5 mg/kg body weight) of enrofloxacin was administered intramuscularly (IM) to the healthy pigs. Using cannulation, the pharmacokinetic properties, including...

The experiment was conducted to evaluate the effect of enrofloxacin induced oxidative stress in liver homogenates of broiler chickens. Total fifty broiler chickens divided into five groups at the age of day 38 were used for this study. Oxidative stress was produced in the chickens with Enrofloxacin at an oral dose of 10 mg/kg b.w. In Enrofloxacin (10 mg/kg b.w) treated group, there was a signif...

Succinate was the major organic acid detected in the hindgut content of pigs suffering from antibiotic-associated diarrhea. Antibiotic-associated diarrhea was induced by an oral dose of polymyxin B sulfate (3,000,000 units/day) or an intramuscular injection of enrofloxacin (0.6 g enrofloxacin/day). In the large intestine of enrofloxacin-treated pigs, Gram-negative facultative anaerobic rods phy...