of different kinds of diseases, including aging, coronary heart disease, inflammation, stroke, diabetes mellitus, rheumatism, liver disorders, renal failure and cancer. Reactive oxygen species (ROS) comprise free radicals such as · O2 (superoxide anion), · OH (hydroxyl radical), H2O2 (hydrogen peroxide) and O2 (singlet oxygen), which can cause cellular injuries and also initiate peroxidation of...

INTRODUCTION Increased levels of C-Reactive Protein are found in 30-60% on hemodialysis patients and it is closely associated with the progression of atherosclerosis, cardiovascular morbidity and mortality. Non enzymatic antioxidants are antioxidants which primarily retain potentially dangerous ions of iron and copper in their inactive form and thereby prevent its participation in the productio...

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with an unknown etiology, whicheffects on many tissues and organs. Therefore, the present study aimed to demonstrate role of therheumatoid in causing oxidative stress by studying level balance between MalondialdehydeMDA (as indicator oxidation) non-enzymatic enzymatic antioxidants blood serumof 95 patients both sexes, whose ag...

Free radicals play an important role in the pathogenesis of tissue damage in many clinical disorders, including atherosclerosis. This study was to investigate lipids and oxidative stress markers among women with 50 healthy non-pregnant compare with 50 healthy pregnant and 50 pregnancy-induced hypertensive subjects and correlate with cardiac troponin I (cTnI) and troponin T (cTnT). The level of ...

In this study we investigated the oxidative stress, antioxidants and inflammatory molecules in patients of acute myocardial infarction (AMI) with diabetes (n = 50) and non-diabetes (n = 50). Fifty healthy subjects were taken as control. The levels of plasma TBARS and ceruloplasmin levels were significantly high in diabetic and non-diabetic AMI patients as compared with control. On the other han...

Present study focuses on the evaluation of butyl p-hydroxybenzoic acid (butylparaben CAS No: 94-26-8) exerted hepatotoxicity in mice. Oral administration of three different doses of butylparaben (40, 20 and 13.33 mg/0.2 mL olive oil/kg b.w./day) for 30 days has resulted in marked increase in lipid peroxidation. The effect was dose-dependent. Biochemical analysis revealed significant (p < 0.05) ...

In this study, the activity of methanol extract of Prosopis cineraria (MPC) was evaluated in N-nitrosodiethylamine (DEN, 200mg/kg) induced experimental liver tumor in male Wistar rats. It was found that the administration of MPC (200 and 400mg/kg) effectively suppressed liver tumor induced by N-nitrosodiethylamine (DEN) as revealed by decrease in N-nitrosodiethylamine (DEN) induced elevated lev...

OBJECTIVES The present study was an attempt at investigating whether the aqueous extract of Emblica officinalis may have an ameliorative effect on ochratoxin-induced lipid peroxidation in the kidney and liver of mice. METHODS Adult male albino mice were orally administered 50 microg (LD, low dose) and 100 microg (HD, high dose) of ochratoxin/0.2 ml of olive oil/animal/day for 45 days. RESUL...

Hepatoprotective activity of hydroalcoholic extract of Luffa acutangula (HAELA) against carbon tetrachloride (CCl4) and rifampicin-induced hepatotoxicity in rats was evaluated and probable mechanism(s) of action has been suggested. Administration of standard drug- silymarin and HAELA showed significant hepatoprotection against CCl4 and rifampicin induced hepatotoxicity in rats. Hepatoprotective...

Currently, there is global attention focused on finding antioxidants from natural sources, due to common synthetic antioxidants such as butylated hydroxyanisole and butylated hydroxytoluene (BHT) being reported to cause adverse effects including enzymatic and lipid alterations[1]. Antioxidants protect the body from free radicals and reactive oxygen species (ROS). ROS activity leads to skin agei...