Formulation of a truly advanced statistical theory of biochemical processes needs simple but realistic models of phenomena underlying microscopic dynamics of proteins. Many experiments performed in the 1980s have demonstrated that within the protein native state, apart from usual vibra-tional dynamics, a rich interconformational (activated) dynamics exists. The slowness of this dynamics makes a...

Abstract There are growing demands by the biodiesel companies to get cheap lipase formulation, preferably in liquid forms, which can give an answer their needs. Thus, many commercial or home-produced enzymes being used this process free form. Among these enzymes, Eversa is a formulation derived from Thermomyces lanuginosus designed for enzymatic production. The potential of promising enzyme her...

Maintaining protein conformational stability and integrity during formulation is critical for developing protein pharmaceuticals. Accordingly, high sensitivity differential scanning calorimetry (HSDSC) and Fourier transform (FT)-Raman spectroscopy were employed to assess conformational stabilities (thermal stability and folding reversibility) and structural integrities, respectively, for three ...

Biomedical adhesives have been found to be an attractive alternative suturing in several circumstances. However, date most of the clinically approved formulations are based on synthetic and highly reactive toxic chemicals. In this work, we aimed combine for first time bioactive properties cationic polysaccharide chitosan its intrinsic electrostatic binding negatively charged tissues with biocom...

Colon specific drug delivery has achieved utmost importance because the colon is an area that is vulnerable to a number of diseases including ulcerative colitis, crohn’s disease, irritable bowel syndrome and carcinomas. And, preservation of formulation in upper GIT to colon is still important step. Treatment of these diseases with a colon-specific drug delivery system provides an interesting al...

This study assessed the effects on plaque in the absence of brushing of two twice-daily mouthrinses, one with an enzymatic-based formulation (Biotène) and one with an antimicrobial chlorhexidine-based formulation (Peridex), and sterile water. Plaque levels were assessed in 23 participants using a 4-day, nonbrushing plaque regrowth model after twice-daily rinsing with sterile water (negative con...

astigmatism’s defect has not yet been formulated in physics and medical physics books theoretically. in this paper, we are trying to formulate the astigmatism’s defect. the results of formulation show that “the degree of astigmatism is negative reverse the distance that vision’s condition of astigmatism’s chart lines change conditions in dimness angle from dimness condition at infinite distance...

nineteen bread wheat genotypes were selected to examine the effect of glycine betaine (gb, 100 mm) on various photosynthetic gas exchange parameters under drought stress and to study the relationship of these parameters with non-enzymatic antioxidants. drought stress caused a significant decline in net co2 assimilation rate (pn), stomatal conductance (gs), intercellular co2 concentration (ci) a...

for the first time in the present study the effects of vanillin, vanillyl alcohol, vanillic acid, as well as the newly synthesized vanillin derivative, bis-vanillin, were investigated on the oxidation of dopamine hydrochloride by mushroom tyrosinase. among them, vanillin and bis-vanillin act as activators, while vanillyl alcohol and vanillic acid exhibited inhibitory effects, the ic50 values be...

introduction: α-amylase is a major form of amylase found in humans and other mammals. it is the special key enzyme involved in carbohydrates breakdown. inhibition of this enzyme could be used in treatment of diabetes. in this study, the effect of ten iranian macrolichens on alpha amylase were tested. methods: different concentrations of the extracts (25, 50 and 75 mg/ml) were incubated with enz...