Retrospective review was performed of children aged <3 years with epileptic spasms at our center from 2004-2010. Short-term (<6 months) and long-term (≥6 months) outcomes were assessed. We included 173 children (104 boys; median age of onset, 6.8 months) with epileptic spasms of known (62%) and unknown (38%) etiology. Treatments included adrenocorticotropic hormone (n = 103), vigabatrin (n = 82...

Epileptic encephalopathies refer to a group of disorders in which the unremitting epileptic activity contributes to severe cognitive and behavioral impairments above and beyond what might be expected from the underlying pathology alone, and these can worsen over time leading to progressive cerebral dysfunction. Several syndromes have been described based on their electroclinical features (age o...

The drug taking habits and compliance of 16 epileptic children were studied by means of a questionnaire, "pill" count and serum antiepileptic drug levels (AEDL). The questionnaire method overestimated patients' compliance while, because of the pharmacokinetics of antiepileptic drugs in children, single outpatients' drug levels may be misleading thereby not always reflecting the true degree of c...

Background: Epilepsy is a common chronic neurological disorder with more than half of cases beginning in childhood. Most patients require long-term, and sometimes life-long, therapy antiepileptic drugs (AEDs). AEDs are associated significant side effects including radiological evidence rickets, decreased bone mineral density (BMD), altered turnover, increased risk fracture.&#x0D; Aim the Study:...

BACKGROUND West Syndrome (WS) represents as a specific epileptic encephalopathy characterised with a unique type of attacks, called infantile spasms, severe forms of abnormalities in electroencephalographic (EEG) records as a hypsarythmias and delays in the psychomotoric development. The characteristics of the disease, mostly affecting male gender, are infantile spasms and typical findings in E...

Dear Editor Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in children (1). Prevailing theories suggest that this disease is caused by the disruption of dopamine transmission in the frontal lobe and frontostriatal pathway (2). The prevalence of such a disorder worldwide is approximately 5.2–12% (1)(2). ADHD is one of the most common disorders followed by ...

BACKGROUND AND AIM Benign epilepsy with centro-temporal spikes (BECTS) is one of the most frequent epileptic syndromes in children. It is placed among the idiopathic localization-related epilepsies. However, the relationship between unilateral or bilateral localization of interictal stereotyped focal spikes on electroencephalogram (EEG) and the effectiveness of anti-epileptic drugs has not been...

PURPOSE Social, cultural, psychological and many other factors significantly impact the lives of epileptic children and their families. Parental concerns towards their children are less known in south Asian children with epilepsy. We aimed to identify the parental concerns regarding their children and adolescents with epilepsy in Sri Lanka. METHODS We carried out qualitative study in 3 distri...

A free-field study of 22 epileptic children, selected on the basis of past electroencephalographic abnormality, identified a group who exhibited a significant increase in epileptiform discharge rate on electroencephalography in a discothèque environment (p less than 0.05). Laboratory investigations showed that these children were activated by a wide range of stimuli, including intermittent phot...