Our previous data demonstrated that type II cGMP-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced MAPK/ERK/JNK-mediated signal transduction through inhibiting the phosphorylation/activation of the epidermal growth factor receptor (EGFR). Since the EGFR also binds with several other ligands as well as EGF, the present study was designed to investigate whether PKG...

The synthesis o f bis(dimethylglyoximato)-cobalt(II) (C oH(dmgH)2) in the a-cages o f a cobalt-exchang­ ed sodium X-zeolite is described. A simple hydration/oxygenation sequence culminating in a superoxo complex, C oni(dm gH)2-H 20 0 ^ has been studied using X-band EPR spectroscopy. The identification o f the precursor species: square-planar C on(dmgH)2, distorted C oH(dmgH)2 and C oM(dmgH)2-2 ...

Two new cobaltous-porphyrin complexes, namely (?-piperazine)-bis[(meso-tetra(para-methoxyphenyl)porphyrinato)]cobalt(II) and (piperazine)[meso-tetra(para-chlorophenyl)porphyrin]cobalt(II) dichloromethane disolvate, with the formulas [{CoII(TMPP)}2(?2-pipz)] (complex 1) [CoII(TClPP)(pipz)]·2CH2Cl2 2), were used efficiently as catalysts in degradation of 4-nitrophenol (4-NP) an aqueous hydrogen p...

Pentacoordinated copper(II) complexes were synthesized from tetradentate ligand N,N-bis (2-methyl-N-methylbenzimidazolyl)hexanediamide. Characterization has been done on the basis of elemental analysis, electronic spectra, IR studies, conductance data, magnetic properties, EPR and x-ray studies for the complexes. From analytical data, the stoichiometry of the complexes has been found to be 1:1 ...

Objective(s): Nanocarriers are drug delivery vehicles, which have attracted the attention of researchers in recent years, particularly in cancer treatment. The encapsulation of anticancer drugs using protein nanocages is considered to be an optimal approach to reducing drug side-effects and increasing the bioavailability of anticancer drugs. Epirubicin (EPR) is an active chemotherapeutic medica...

Keywords: Self-learning Finite element Evolutionary computation Material modelling EPR a b s t r a c t In this paper an EPR-based self-learning method is presented for modelling the constitutive behaviour of materials using evolutionary polynomial regression (EPR). The proposed approach takes advantage of the rich stress–strain data buried in non-homogenous structural tests. The load–deformatio...

The oxygen-atom transfer reaction from the bis(mu-oxo)dicopper(III) complex [Cu(III)(2)(mu-O)(2)(L)(2)](2+), where L =N,N,N',N' -tetraethylethylenediamine, to PPh(3) has been studied by UV-vis, EPR, (1)H NMR and Cu K-edge X-ray absorption spectroscopy in parallel at low temperatures (193 K) and above. Under aerobic conditions (excess dioxygen), 1 reacted with PPh(3), giving O=Ph(3) and a diamag...

A manganese-dependent 3,4-dihydroxyphenylactate 2,3-dioxygenase from Arthrobacter globiformis strain CM-2 (MndD) cloned in Escherichia coli has been purified to homogeneity. Sedimentation equilibrium analysis indicates an alpha 4 homotetrameric holoenzyme structure (4 x 38,861 Da). Steady-state kinetic analysis of MndD with a variety of substrates and inhibitors yields very similar relative rat...

The alternative oxidase (AOX) is a ubiquinol oxidase found in the mitochondrial respiratory chain of plants as well as some fungi and protists. It has been predicted to contain a coupled diiron center on the basis of a conserved sequence motif consisting of the proposed iron ligands, four glutamate and two histidine residues. However, this prediction has not been experimentally verified. Here w...

the interaction of magnesium hydrate at the phosphate oxygen atom of the pyrimidine nucleotides (cmp,ump,dtmp) were studied at the hartree-fock level theory. we used lanl2dz basis set for mg and 6-31g* basis set for atoms.the basis set superposition error (bsse) begins to converge for used method/basis set. the gauge-invariant atomic orbital (giao) method and the continuous-set-of-gauge-transfo...