Interleukin-10 (IL-10) terminates inflammatory immune responses and inhibits activation and effector functions of T-cells, monocytes, macrophages and dendritic cells. IL-10 has also been found to be a key cytokine expressed by subpopulations of regulatory T-cells. In this report, we describe the generation and characterization of three monoclonal antibodies (mAbs) to equine IL-10. The antibodie...

Eastern equine encephalomyelitis (EEE), western equine encephalomyelitis (WEE), and Venezuelan equine encephalomyelitis (VEE) viruses are mosquito-borne pathogens that can cause nonspecific illnesses and encephalitis in equids (horses, mules, burros, donkeys and zebras) and humans in the Americas. Some of these viruses also affect birds and occasionally other mammals. No specific treatment is a...

Description: Equine Pharmacology combines highly practical therapeutic guidance with reliable scientific background information to provide a clinically relevant resource. Taking a body systems approach to the subject, the book offers the equine clinician with fast access to drug options for a given disease, with additional information available for reference as needed. Logically organized to le...

Clinique Equine Desbrosse, St. Lambert des Bois, France1, Department of Veterinary Clinical Science and Animal Husbandry, The University of Liverpool, South Wirral2, Cotts Equine Hospital, Narberth, Pembrokeshire, UK3, Département de morphologie et pathologie, Faculté de Médecine Vétérinaire de l’Université de Liège, Liège, Belgium4, Clinique de Genainville, Genainville, France5, Equine Clinic,...

The field of equine veterinary practice is in an ever-evolving state, requiring current technologies to be constantly evaluated for new applications. The specific use of gene therapy in the horse is a novel application. The authors want to help familiarize the equine practitioner with the concept of gene therapy, and introduce its use and potential future benefits for the equine industry in the...

Introduction: The equine stifle is a complex joint that may be the site of equine lameness, but diagnosis of pain can be frustrating using standard imaging techniques. Magnetic resonance imaging (MRI) of the equine distal limb has led to improvements in understanding of lameness pathogenesis. Until recently, MR imaging has been limited to the distal limb, but recently the use of MRI for clinica...

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The most accurate method for the diagnosis of equine protozoal myeloencephalitis is the identification of clinical signs and the presence of anti-Sarcocystis neurona antibodies in cerebrospinal fluid; acupuncture is not useful. Author’s addresses: Equine Internal Medicine Consulting, 3288 Valhalla Dr., Lexington, KY 40515 (Fenger) and Dept. of Veterinary Science, 108 Gluck Equine Research Cente...

This study identifies nonimmune binding of equine immunoglobulin by the causative organism of contagious equine metritis. Immunoglobulin binding to the bacterium was strongest for immunoglobulin G (IgG) and less for IgM; IgA was not bound. Binding of equine IgG was inhibited by human IgG, but not by IgG of domestic animals. Immunoglobulin binding by the bacterium appeared to be directed towards...

The equine periodontal ligament (PDL) is a fibrous connective tissue that covers the intra-alveolar parts of the tooth and anchors it to the alveolar bone-it, therefore, provides a similar function to a tendinous structure. While several studies have considered the formation and structure of tendons, there is insufficient information particularly on the molecular composition of the PDL. Especia...