The lupus erythematosus cell (L.E. cell) phenomenon is usually regarded, if properly interpreted, as being almost specific for systemic lupus erythematosus (Wilkinson and Sacker, 1957). On the other hand, too rigid an outlook may lead to diagnostic errors or retard progress in the understanding of other diseases. Careful repeated examination of the blood of patients with classical rheumatoid ar...

Lupus erythematosus profundus, a form of chronic cutaneous lupus erythematosus, is a rare inflammatory disease involving in the lower dermis and subcutaneous tissues. It primarily affects the head, proximal upper arms, trunk, thighs, and presents as firm nodules, 1 to 3 cm in diameter. The overlying skin often becomes attached to the subcutaneous nodules and is drawn inward to produce deep, sau...

matosus. A similar case of Sjogren syndrome and subsequent development of systemic lupus erythematosus has been reported in a 12 year old boy.3 In our patient, two points remain to be clarified, whether the seizures were the first symptom of systemic lupus erythematosus central nervous system involvement and whether any relation can be found between the phenobarbitone treatment and the onset of...

objective systemic lupus erythematosus (sle), an autoimmune systemic disease with unknown etiology, affects virtually every part of the body; involvement of the central nervous system (cns) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (sle) patients and is the least understood aspect of the disease. neutropenia is very uncommon in childhood lupus. true n...

OBJECTIVE To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity, laboratory findings and treatment features. METHODS We screened consecutive childhood-onset systemic lupus erythematosus patients in a longit...

BACKGROUND Thyroid autoimmunity is considered the most common type of organ-specific autoimmune disorder and can be associated with other autoimmune endocrine disorders or non-endocrine diseases. Systemic lupus erythematosus is a prototypical autoimmune disorder with multifactorial etiology. The pathogenesis and development of the disease may result from a loss of immune tolerance and the resul...

BACKGROUND AND PURPOSE Multiple sclerosis and neuropsychiatric systemic lupus erythematosus are autoimmune diseases with similar CNS inflammatory and neurodegenerative characteristics. Our aim was to investigate white matter tract changes and their association with cognitive function in patients with MS and those with neuropsychiatric systemic lupus erythematosus compared with healthy controls ...

Systemic lupus erythematosus is a group of diseases that seem to become separate entities by etiology in the near future. Its pathogenesis remains elusive; however, multifactorial interactions among genetic and environmental factors may be involved. Systemic lupus erythematosus is the perfect prototype of autoimmune disorder with multiple derangements, starting from innate immunity to adaptive ...

macrophage activating syndrome (mas) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, still's disease, polyarteritis nodosa. it is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. a 27 yr. old female patient was admitted in shahid mostafa khomeini hospital (tehra...

background: antiphospholipid antibody syndrome (aps) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (sle). anticardiolipin antibody (acl) of igg and/or igm isotype in blood, measured by a standardized elisa is the most acceptable laboratory criteria. aps igg isotype, particularly igg2 subclass is more strongly associated ...