Stomach is considered the “gold standard” as an esophageal substitute after esophagectomy. Reflux disease is considered an unavoidable consequence of esophageal resection followed gastric interposition. Reflux esophagitis shows a progression from inflammation to erosions and to the development of columnar lined metaplasia. With the use of a gastric interposition, the most popular option to reco...

BACKGROUND Several studies have evaluated associations between the characteristics of patients with esophageal and gastric cancer and survival, but these associations remain unclear. We described the distribution of demographic and lifestyle factors among patients with esophageal and gastric cancer in Japan, and investigated their potential effects on survival. METHODS Between 2003 and 2007, ...

presentedwithepigastralgiaandtransientsubsternaldiscomfortjustafterswaIlowingfood, In this patient, endoscopic examination revealed multiple esophageal ulceration and kissingtype gastric ulceration. The esophageal ulcers were not improved by frequent antacid therap7 for six weeks, while gastric ulcers responded we]1 to the therapl. Steroid therapy was begun and esophagoscopy revealed scarred ul...

BACKGROUND Incidence rates for adenocarcinomas of the esophagus and gastric cardia have risen steeply over the last few decades. To determine risk factors for these tumors, we conducted a multicenter, population-based, case-control study. METHODS The study included 554 subjects newly diagnosed with esophageal or gastric cardia adenocarcinomas, 589 subjects newly diagnosed with esophageal squa...

BACKGROUND Gastroesophageal reflux and progressive esophageal dilatation can develop after gastric banding (GB). HYPOTHESIS Gastric banding may interfere with esophageal motility, enhance reflux, or promote esophageal dilatation. DESIGN Before-after trial in patients undergoing GB. SETTING University teaching hospital. PATIENTS AND METHODS Between January 1999 and August 2002, 43 patien...

CD97 expression is related closely to the dedifferentiation and tumor stage in thyroid carcinomas. We systematically examined the role of CD97 and its closest relative, EMR2, in normal and malignant gastric, esophageal, and pancreatic tissue. The normal tissues were EMR2-, whereas CD97 was expressed slightly in the parietal cells of gastric mucosa and in exocrine pancreatic cells. Interestingly...

BACKGROUND Geographical variation and temporal trends in the incidence of esophageal and gastric cancers vary according to both tumour morphology and organ subsite. Both diseases are among the deadliest forms of cancer. The incidence and survival rates for gastric and esophageal carcinoma in British Columbia (BC) between 1990 and 1999 are described. METHODS Incidence data for the period 1990 ...

We examined the effect of leminoprazole (an acid pump inhibitor) on reflux esophagitis induced in rats. Intragastrically administered leminoprazole significantly and dose-dependently protected the esophageal mucosa against the reflux of gastric contents, without affecting gastric acid secretion. However, it had no effect on the esophagitis when administered intraduodenally, despite its signific...

it is well established that the esophageal distention (ed) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ed on gastric acid secretion has not been investigated. the aim of this study was to investigate the effect of ed on basal and stimulated gastric acid secretion. methods: adult male wistar rats (200-240 g) were deprived of food but not the water 24 h b...

BACKGROUND Dietary N-nitroso compounds and endogenous nitrosation are important carcinogenic factors, but human evidence of their role is scarce for esophageal cancer and inconsistent for gastric cancer. OBJECTIVE We studied the relation between risks of esophageal and gastric cancer subtypes and dietary intake of N-nitrosodimethylamine, heme iron, nitrite, and nitrate in the Netherlands Coho...