Approximately 75% of adults over the age of 65 years are affected by two or more chronic medical conditions. We provide a conceptual justification for individualized absolute risk calculators for competing patient-centered outcomes (PCO) (i.e. outcomes deemed important by patients) and patient reported outcomes (PRO) (i.e. outcomes patients report instead of physiologic test results). The absol...

We have established a new convergent scheme to treat analytically nucleon-nucleon interactions from a chiral effective field theory. The Kaplan-Savage-Wise (KSW) amplitudes are resummed to fulfill the unitarity or right hand cut to all orders below pion production threshold. This is achieved by matching order by order in the KSW power counting the general expression of a partial wave with resum...

OBJECTIVES: HTA bodies increasingly require accurate survival estimates to provide reliable recommendations. It is argued that access to individual patient data (IPD) can improve their accuracy. This poster aims to assess to what degree extracting IPD from published Kaplan-Meier (KM) curves helps improve extrapolated survival estimates. Some methods currently used for HTA submissions fit a surv...

BACKGROUND At present, limited clinical data is available regarding survival rates of patients co-infected with human immunodeficiency virus (HIV)/tuberculosis (TB) in developing countries. OBJECTIVES The present study aimed to evaluate the effect of HIV infection on the survival chances of active TB adults who disclosed their symptoms of TB in this part of Iran. PATIENTS AND METHODS The re...

BACKGROUND A plethora of clinical studies have assessed the benefits of implantable cardioverter defibrillators (ICDs) and supported their use in clinical practice. However, evidence on the safety and efficacy of ICDs appears insufficient to support expansion of their use in clinical practice, and more information on their impact in real life settings is warranted. This paper aims to investigat...

Consider a long term study, where a series of dependent and possibly censored failure times is observed. Suppose that the failure times have a common marginal distribution function, but they exhibit a mode of time series structure such as-mixing. The inferences on the marginal distribution function are of our interest. The main results of this paper show that under some regularity conditions, t...