نتایج جستجو برای: estrogen response element

تعداد نتایج: 1193709  

Journal: :Cancer research 2003
Li Hua Wang Xiao Yi Yang Xiaohu Zhang Kelly Mihalic Weihua Xiao William L Farrar

Breast cancer, the most common malignancy in women, has been demonstrated to be associated with the steroid hormone estrogen and its receptor (ER), a ligand-activated transcription factor. Therefore, we developed a phosphorothiolate cis-element decoy against the estrogen response element (ERE decoy) to target disruption of ER DNA binding and transcriptional activity. Here, we showed that the ER...

ژورنال: Anatomical Sciences Journal 2011
Mohammadzadeh, Farzaneh, Rastegar , Tayebeh, Eftekharzadeh, Mina, Nobakht , Malihe,

Purpose: The aim of our study is the assesment of estrogen receptor a expression in pyramidal neurons in rat CA 1hippocampus that has been ovariectomized. By using the estrogen antagonist, Tamoxifen level of expression of estrogen receptor a in these cells. Materials and Methods: To study the effect of 17- b estradiol and tamoxifen on estrogen receptors a, expression in hippocampus rats of Wist...

Journal: :international journal of hematology-oncology and stem cell research 0
seyed asadollah mousavi hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran, iran vahid moazed hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran, iran niayesh mohebbi research center for rational use of drugs and department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran molouk hadjibabaie faculty of pharmacy, and research center for rational use of drugs, tehran university of medical sciences, tehran, iran kamran alimoghaddam hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran, iran babak bahar hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran, iran

abstract background hemorrhagic cystitis(hc)is one of the most challenging complications in hematopoietic stem cell transplantation(hsct). estrogen is one of the suggested treatments for controllingthis problem. material and methods we performed a randomizedcase - controlled study to evaluate the efficacy of oral conjugated estrogen on hc management in 56hsct patients.patients were randomly ass...

2000
ROBERT A. SHAPIRO CONG XU DANIEL M. DORSA

Neuronal expression of vasopressin messenger RNA (mRNA) and peptide has been shown to be estrogen dependent. A 5.5-kb genomic DNA fragment, 59 of the AVP coding region, was used in luciferase reporter assays to measure transcriptional activation by either estrogen receptor a or b in response to various treatments. ERa and ERb displayed differential regulation of the AVP promoter. SK-N-SH cells ...

2012
Sachindra R. Joshi Yaw C. Sarpong Ronald C. Peterson William M. Scovell

High mobility group protein 1 (HMGB1) interacts with DNA and chromatin to influence the regulation of transcription, DNA repair and recombination. We show that HMGB1 alters the structure and stability of the canonical nucleosome (N) in a nonenzymatic, ATP-independent manner. Although estrogen receptor (ER) does not bind to its consensus estrogen response element within a nucleosome, HMGB1 restr...

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

2017
Yao-Chang Chiang Ruey-Yun Wang Chieh-Liang Huang Shue-Hwa Chen Wen-Jing Ho Hsien-Yuan Lane Ing-Kang Ho Hwei-Ting Yang Wen-Lung Ma

Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen-response element single nucleotide polymorphism (ERE-SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated...

Journal: :Hypertension 2016
Ko-Ting Lu Henry L Keen Eric T Weatherford Maria Luisa S Sequeira-Lopez R Ariel Gomez Curt D Sigmund

Enzymatic cleavage of angiotensinogen by renin represents the critical rate-limiting step in the production of angiotensin II, but the mechanisms regulating the initial expression of the renin gene remain incomplete. The purpose of this study is to unravel the molecular mechanism controlling renin expression. We identified a subset of nuclear receptors that exhibited an expression pattern simil...

Journal: :Environmental Health Perspectives 2000
G N Nikov N E Hopkins S Boue W L Alworth

Epidemiologic and experimental studies support the hypothesis that dietary estrogens from plant sources (phytoestrogens) may play a role in the prevention of breast and prostate cancer. The molecular mechanisms for such chemopreventive effect are still unclear. We investigated the possibility that phytoestrogens may bind differentially to estrogen receptor proteins (ER[alpha] and ERss) and affe...

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