background: local ethical committees in medical sciences in iran were established in 1999 in order to assess and evaluate the observance of ethical standards throughout the universities and research centers. the purpose of this study is to analyze the situation of local ethical committees in order to develop research ethics guideline. methods: for this cross-sectional study which has been condu...

In this article we present an approach for tackling three important aspects of text normalization: sentence boundary disambiguation, disambiguation of capitalized words in positions where capitalization is expected, and identification of abbreviations. As opposed to the two dominant techniques of computing statistics or writing specialized grammars, our document-centered approach works by consi...

The immune microenvironment is considered a major obstacle to generating an effective antitumor immune response. Checkpoint inhibitors manipulate the co-stimulatory response between antigen-presenting cells and immune cells-or between the tumor and immune cells-to elicit an antitumor immune response that would have otherwise been suppressed. Checkpoint inhibitors have shown great promise in the...

The ethical review of research on human beings, and indeed the ethical review of broader ranges of human activity, is a growth industry. I want to look here at the ethical review of research on humans and raise some questions about the direction it is taking. I am pessimistic about where the institutions that we have set up are leading us and I want to sound a warning note and suggest some chan...

Health research initiatives worldwide are growing in scope and complexity, particularly as they move into the developing world. Expanding health research activity in low- and middle-income countries has resulted in a commensurate rise in the need for sound ethical review structures and functions in the form of Research Ethics Committees (RECs). The urgent need for continued capacity development...

although allameh majlisi has not intended to write a distinct ethical book on ethics or to present a coherent moral system in various volumes of behar al-anwar, but we can deduce a comprehensive ethical system through examination of the different discussions he has made about different  verses and traditions. this deduced ethical system not only emphasizes the role of reason in explaining the t...

more than a decade ago, personalized medicine was presented in modern medicine. personalized medicine means that the right drug should be prescribed for the right patient based on genetic data. no doubt is developing medical sciences, and its shift into personalized medicine complicates ethical challenges more than before. in this review, we categorized all probable ethical considerations of pe...