The absorption of the nonionic contrast medium iohexol, the clearance tracer 51Cr-ethylenediaminetetraacetic acid, and the blood-pool marker 125I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and 51Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and higher achieved blood levels than a suba...

A 56-yr-old man with hypogonadism, gynecomastia, and mental retardation was evaluated for chromosome constitution and thrombocytopenia. Chromosomal analysis demonstrated the mosaicism of 48, XXYY and 47, XXY in the peripheral lymphocytes. Twenty out of twenty-five cells were 48, XXYY karyotype and the remaining five were 47, XXY karyotype. Thrombocytopenia was the EDTA-dependent pseudothrombocy...

The lysis of certain gram-negative bacteria by ethylenediaminetetraacetic acid (EDTA) and lysozyme was first reported by Repaske (7, 8). Lysis by EDTA alone was reported for Pseudomonas aeruginosa (3, 8), Vibrio succinogenes (9), and Alkaligenes faecalis (3). The mechanism for lysis by EDTA (2) in conjunction with lysozyme has been attributed to the interruption of the integrity of the cell sur...

Interest in ethylenediaminetetraacetic acid (EDTA) arises from its ability to combine with metal ions to form water-soluble chelates. Several important biological applications have been made of this property. The material has been shown to be effective (a) in mobilizing radioactive elements such as Pu, Am, and Y from the skeleton (1, 2), (b) as a valuable therapeutic agent in the treatment of p...

Cultures of chick heart fibroblasts were perfused with the chelating agent ethylenediaminetetraacetic acid (EDTA). Cellular responses were observed under phase optics and recorded by time-lapse cinemicrography. In interphasic fibroblasts, EDTA induces cellular contraction followed by continuous protrusion and retraction of ectoplasmic blebs ("surface bubbling"), formation of motile vermiform pr...