2014 Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in the UK, with an estimated prevalence of 10.4%. CRS has been shown to have a significant impact on quality of life, worse in some domains of the Short Form-36 than COPD or angina. It carries a high socioeconomic burden; with estimated healthcare costs in the USA of $772/patient/year (2011). Untreated, CRS may also ca...

Pharmacokinetics is a fundamental scientific discipline that underpins applied therapeutics. Patients need to be prescribed appropriate medicines for a clinical condition. The medicine is chosen on the basis of an evidencebased approach to clinical practice and assured to be compatible with any other medicines or alternative therapies the patient may be taking. The design of a dosage regimen is...

In clinical practice, physicians often use certain strategies based on guidelines or recommendations from experts. This is because in the era of evidencebased medicine, clinicians are more willing to make “evidence-based” decisions. This is also the case in the field of lipid-lowering therapy. The term “lipidlowering therapy” does not simply refer to items with abnormal values in the lipid prof...

The primary purpose of the Total Recall Track is to evaluate, through controlled simulation, methods designed to achieve very high recall – as close as practicable to 100% – with a human assessor in the loop. Motivating applications include, among others, electronic discovery in legal proceedings [3], systematic review in evidencebased medicine [6], and the creation of fully labeled test collec...

SEE PAGE 126 T he hallmark of ST-segment elevation myocardial infarction (STEMI) is thrombotic occlusion of an epicardial vessel. As many as 50% of patients undergoing primary percutaneous coronary intervention (PCI) demonstrate distal embolization and microvascular obstruction despite achieving normalized epicardial flow. This is associated with increased infarct size, reduced recovery of vent...

One of the traditional goals of internist geriatricians and of family physicians providing care for elderly patients has been to review and reduce the amount of medication patients are taking. This can be one of the great pleasures of geriatric medicine, with obvious and proven benefits for older patients. Polypharmacy can be defined as the concomitant use of many medications. The more medicati...

n t odern healthcare operates under the banner of “evidencebased” medicine. The pursuit of such evidence, however, is ot exclusively driven by need, but by the vailability of funds, which in turn deends partly on the likelihood of profit. ore portentously, the pursuit of data is ounded by the prevailing conceptions of iological plausibility. This essay makes he case that such borders are not re...

W h i l e advocating the need for integration of modern with traditional health care strategies, the chapter 1 elaborates evolution of health care system in human societies, the current diversity of health related challenges in different countries/ societies, the remarkable advances in biomedical sciences in recent times, the traditional and complementary medicine systems in different parts of ...

YES. There are many points of agreement between our position and that of Drs Labrecque and Cauchon.1 We agree that data from scientific research are an important component of medicine and are one of the key distinguishing features of modern medicine. We agree that medicine needs to incorporate patient preferences and values and that clinicians should be expert and humane. However, we think it i...