BACKGROUND Fat grafting is an increasingly popular method of augmentation/reconstruction of soft tissue defects. However, the clinical unpredictability and high resorption rates of the grafts remain problematic. Cellular stress from the harvest and the ensuing ischemic episode may be the cause of this. Cellular stress activates the p38 mitogen-activated protein kinase (MAPK) signaling pathway. ...

OBJECTIVE To assess the value of antenatally determined observed to expected fetal lung area to head circumference ratio (LHR) in the prediction of postnatal survival in isolated, congenital diaphragmatic hernia (CDH). METHODS Two groups of fetuses were examined. The first group included 650 normal fetuses at 12-32 weeks' gestation, and the data collected were used to establish a normal range...

BACKGROUND Because reported survival after venous thromboembolism (VTE) varies widely, we performed a population-based retrospective cohort study to estimate survival, compare observed with expected survival, and determine predictors of short-term (< or =7 days) and long-term survival (>7 days) after VTE. METHODS We followed the 25-year (1966-1990) inception cohort (n = 2218) of Olmsted Count...

BACKGROUND Until 1998 in Japan, very few institutions were treating prostate cancer solely with radiotherapy (RT) >70 Gy and most were using < or =65 Gy in combination with hormone therapy. The present study reports the long-term results of RT combined with hormone therapy for localized and locally advanced prostate cancer. METHODS We investigated 57 patients who were treated by external beam...

patients and methods we investigated the timing and frequency of acute rejection episodes related to long-term patient-graft survival in taleghani hospital between 1990 and 2011. recipients were divided into three groups as group-1 (no rejection), group-2 (early acute rejection [ear]: less than 3-months) and group-3 (late acute rejection [lar]: after 3 months of transplant). conclusions lar had...

Abstract In theory, expected survival probabilities used in the derivation of relative survival ratios (RSR) are determined from a control group free of the cancer under study. In practice, expected survival is typically estimated from general population life tables-which include people previously diagnosed with cancer-potentially leading to an overestimation of relative survival. Data are from...

BACKGROUND In theory, expected survival probabilities used in the derivation of relative survival ratios (RSR) are determined from a control group free of the cancer under study. In practice, expected survival is typically estimated from general population life tables--which include people previously diagnosed with cancer--potentially leading to an overestimation of relative survival. DATA AN...

Long-term survival was examined for 218 patients with Alzheimer's disease (AD) and 115 patients with multi-infarct dementia (MID). The 14-year survival rate for AD was 2.4% versus an expected rate of 16.6%, and for MID 1.7% versus 13.3% expected. MID showed a more malignant natural course than AD. Men carried a less favourable survival prognosis than women, both in AD and MID: the relative risk...

BACKGROUND AND OBJECTIVE In recent years, two predictive equations to estimate median expected survival at diagnosis for patients affected with Hodgkin's disease have been developed at the University of Pavia Medical School. The present retrospective work was aimed at testing correlation between mean survival estimated using the two equations and observed survival, and at comparing the results ...

The representative guidelines do not recommend androgen deprivation therapy (ADT) as a primary treatment for localized prostate cancer. However, in clinical practice, the use of primary ADT for localized prostate cancer has been widespread, especially among older patients. We performed a retrospective review of the efficacy of primary ADT for localized prostate cancer and compared their outcome...