Background Gray zone or infarct heterogeneity, defined as the admixture of necrotic and viable myocardium at the periphery of myocardial infarction (MI), has been noted to be a modulator of cardiac outcomes. Most studies have not reported a direct correlation between infarct core and the zone of heterogeneity. Furthermore, no large population based studies have examined the burden of undiagnose...

The intratumor heterogeneity has been recognized to characterize cancer cells impairing the efficacy of cancer treatments. We here propose an extension of constraint-based modeling approach in order to simulate metabolism of cell populations with the aim to provide a more complete characterization of these systems, especially focusing on the relationships among their components. We tested our m...

PURPOSE To develop a quantitative understanding of scanning laser polarimetry (SLP) for retinal nerve fiber layer (RNFL) assessment in glaucoma diagnosis and management. METHODS The Mueller calculus was used to model the polarization optics of SLP. A birefringent retinal structure (RNFL or macula) was represented as a circularly symmetric linear retarder with a radial slow axis. The birefring...

The study investigates the impact of taxation on the Nigerian economy for the period 1994 -2012.The dependent variables used in the model includes: Gross Domestic Product (GDP) as a parameter for measuring economic growth, Inflation and unemployment. The objective is this study is to determine how taxation affects these macroeconomic variables. To avoid spurious results, the data set collected ...

A systematic study of the across scale coupling phenomenology in EM scattering problems is addressed using the theory of multiresolution decomposition and orthogonal wavelets. By projecting an integral equation formulation of the scattering problem onto a set of subspaces that constitutes a multiresolution decomposition of L 2 (R), one can derive two coupled formulations. The rst governs the ma...

Hourly streamflow timing, as revealed by diurnal fluctuations in discharge in snowfed watersheds, provides a new tool for understanding transport times and processes in river basins. Travel time delays at different basin scales were measured in nested subbasins (6 to 775 km) of the Tuolumne River in Yosemite National Park throughout the spring 2002 and 2003 melt seasons. The travel time increas...

This paper develops a firm-dynamics model with heterogenous firms and endogenous currency debt composition to jointly study financing and investment decisions in developing economies. In our model, foreign currency borrowing arises from a trade-off between aggregate deviations from the risk-free uncovered interest rate parity and firms’ growth potential. Crucially, there is crosssectional heter...

This study examines experimentally, in situ, the influence of four scales of heterogeneity (0, 1, 10, 100 mm) and the hierarchical combination of those scales of heterogeneity (0 + 1 + 10, 0 + 1 + 100, 0 + 10 + 100, 0 + 1 + 10 + 100 mm) on the early establishment of a sessile marine littoral epibenthic community. The study was carried out in St. Andrews, New Brunswick (Canada) from July to Octo...

The LLS stock market model is a model of heterogeneous quasi-rational investors operating in a complex environment about which they have incomplete information. We review the main features of this model and several of its extensions. We study the effects of investor heterogeneity and show that predation, competition, or symbiosis may occur between different investor populations. The dynamics of...