Clavulanate is a broad-spectrum beta-lactamase inhibitor, with activity against many of the chromosomally and plasmid-mediated beta-lactamases of both Gram-positive and Gram-negative bacteria. Although clavulanate has minimal antibacterial activity in vitro, accumulating evidence suggests that it may have an effect on pathogenic bacteria regardless of beta-lactamase production. Like other beta-...

BACKGROUND & OBJECTIVE Currently, the use of beta-lactamase inhibitors in combination with beta-lactam antibiotics represents an effective measure to combat a specific resistance mechanism of beta-lactamase producing organisms. Knowledge about the susceptibility profile of bacteria to different combination agents available is essential to guide appropriate treatment of severe infections in hosp...

Evaluation of an Agar Dilution Method for Identification of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae in the Environment

background: treatment of chronic sinusitis is complicated due to increase of antibiotic-resistant bacteria. the aim of this study was to determine the multidrug resistance (mdr) pattern of the bacteria causing chronic sinusitis in north of iran. methods: this cross-sectional study was carried out on patients with chronic sinusitis. bacterial susceptibility to antimicrobial agents was determined...

TEM- or SHV-type extended-spectrum beta-lactamases(ESBLs) are of clinical concern in Europe and the United States, whereas bacterial strains producing such types of ESBLs had not been reported in Japan for many years. Toho-1, a different type class A ESBL, has been reported in 1995, in which any prototypical enzyme has not been identified so far. At present Toho-1 is the major ESBL in Japan, ho...

Introduction / objectives Healthcare-associated infections (HAI) constitute major health care problem from their frequency, cost and gravity. Fecal carriage of extended-spectrum beta-lactamase (ESBL)-producing isolates has mainly been detected in HAI, and few studies have evaluated fecal carriage during non-outbreak situations and among patients in the community. This study was undertaken to de...