conclusions we found a marked increase in the incidence of non-albicans species (48.2%) among neutropenic patients. only a few strains failed to produce extracellular enzymes. finally, in addition to fluconazole, caspofungin can be considered as the first line treatment against candida species among neutropenic patients. results a total of 110 yeast strains isolated from urine and oral cavities...

background and purpose: microorganism-based synthesis of nanostructures has recently been noted as a green method for the sustainable development of nanotechnology. nowadays, there have been numerous studies on the emerging resistant pathogenic bacteria and fungal isolates, the probable inability of bacteria and fungi to develop resistance against silver nanoparticles’ (snps) antibacterial, ant...

The kynurenine pathway (KP) is a major route of L-tryptophan catabolism resulting in the production of the essential pyridine nucleotide nicotinamide adenine dinucleotide, (NAD(+)). Up-regulation of the KP during inflammation leads to the release of a number of biologically active metabolites into the brain. We hypothesised that while some of the extracellular KP metabolites may be beneficial f...

It has been hypothesized that neocortical damage is accompanied by secondary changes in other brain areas (the shock or diaschisis of von Monakow), which contributes to initial non-specific behavioral depression. The relation between behavioral changes and dopamine (DA), serotonin (5-HT), and their metabolites, measured with intracerebral microdialysis in freely moving rats and by tissue assay ...

Staphylococcus aureus alpha-toxin (Hla) is a potent pore-forming cytotoxin that plays an important role in the pathogenesis of S. aureus infections, including pneumonia. The impact of Hla on the dynamics of the metabolome in eukaryotic host cells has not been investigated comprehensively. Using 1H-NMR, GC-MS and HPLC-MS, we quantified the concentrations of 51 intracellular metabolites and asses...

Nonsteroidal anti-inflammatory drugs (NSAIDs) including sulindac have shown potent chemopreventive and tumor regressive effects against colorectal cancer, the second leading cause of cancer death in the United States. However, the mechanisms by which sulindac inhibits tumor cell growth are not completely understood. We previously reported that sulindac metabolites inhibit the mitogen-activated ...

Metabolites from clove (Syzygium aromaticum L.) have been extensively studied for various pharmacological uses, including quercetin. Endophytic bacteria isolated plant tissues can produce similar secondary metabolites as their host plants. However, little is known about the antioxidant activity of endophytic bacterial extract leaves. Amongst potential groups, genera Bacillus widely a source ant...

Abstract Exosome is nanosized tiny membrane‐bound vesicles and a subpopulation of extracellular (EVs). In general, it participates in intercellular communication acts as messenger several pathological complications. cancer interlink the most exciting domain current research. The internal molecular cargos (proteins, lipids, metabolites, miRNA, DNA) tumor derived exosomes (TEXs) are capable trans...

The extracellular and intracellular metabolites formed upon exposure of activated sludge microorganisms to a sublethal concentration of N-ethylmaleimide were monitored by liquid chromatography with ion trap mass spectrometry. The metabolite N-ethylsuccinimido-S-glutathione (m/z 433) was converted rapidly to N-(2-oxoethyl)-2,2-(propionylamino)propanamide (m/z 187) and N-ethylmaleamic acid (m/z 1...