INTRODUCTION The diagnosis of Parkinson's disease is mainly clinical. DaT SCAN may help in difficult cases. Depression is also a clinical diagnosis and is common and persistent symptom in Parkinson's disease. Dementia is very often in Parkinson's disease, but usually not at the first stages. The treatment of each of the above symptoms is difficult and a lot of times individualized. CASE PRESE...

BACKGROUND Several reports on patients with chronic schizophrenia suggest that atypical versus typical antipsychotics are expected to lead to better quality of life (QOL) and cognitive function. Our aim was to examine the association of chronic treatment with typical or atypical antipsychotics with cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidal symptoms in long-h...

BACKGROUND Exertional heatstroke is a life-threatening condition with high mortality because of the rapid progress of multiple organ dysfunction syndrome even if aggressive treatments are initiated rapidly. Mild to moderate hepatic injury is common in exertional heatstroke, while fulminant liver failure is rare. Extrapyramidal symptoms and pulmonary aspergillosis secondary to liver failure indu...

BACKGROUND Depressive symptoms are common in schizophrenia and are considered core features of the disorder. The purpose of the present study was to examine the relationship between depressive symptoms and subjective well-being in newly admitted patients with schizophrenia. METHODS Eighty newly admitted patients were comprehensively evaluated for subjective well-being, schizophrenic symptoms,...

Extrapyramidal symptoms (EPS) associated with antipsychotic medication can provoke severe discomfort and disability. Some instruments have been proposed to assess EPS, but they are not widely used in clinical settings. This paper aims to provide a translational tool for the detection of EPS: lacunarity of patients’ handwritings. Lacunarity is a measure, taken from fractals studies, that describ...

Selective estrogen receptor modulators (SERMs) such as raloxifene have already shown beneficial effects on negative, positive and general psychopathology symptoms in postmenopausal women with schizophrenia. The purpose of the present investigation was to assess the efficacy of raloxifene as an adjuvant agent in the treatment of men with chronic schizophrenia in an 8-week double-blind and placeb...

Methanol is a highly toxic substance and acute methanol poisoning produces severe metabolic acidosis and serious neurological symptoms, including severe visual impairment, extrapyramidal signs and coma. We present three cases of accidental methanol intoxication and discuss the MRI findings.

Investigators from Child Neurology and Pediatrics, University of Texas Health Science Center, Houston, report extrapyramidal symptoms in a 13-year-old boy with a psychiatric history of schizophrenia, bipolar disorder, ADHD, and autism, responsive to combination risperidone, oxcarbazepine, and MPH.

The paper defines neuroleptic malignant syndrome and analyses its incidence, predisposing factors, etiology, pathological anatomy and pathogenetic hypotheses. Symptomatology consists of three principal symptoms: extrapyramidal symptoms, hyperthermia, deregulation of the autonomic nervous system. The differential diagnosis of other similar conditions is outlined together with a proposal for a tr...