OBJECTIVE To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus. METHODS Type 1 diabetes was induced with streptozotocin in rats. Tear production was measured by the Schirmer test, and corneal sensitivity, by an esthesiometer. Eye drops of 10(-5)M NTX or sterile vehicle were ad...

this is the second report of conjunctival sac pinworm infection in the literature. the patient was treated with garlic juice, which was prepared as an eye drop. the first case reported from india was a is year old girl who had pinworm infection of her left eye. she had wonnexpulsion•at night. our case was a 13 year old girl who had worm infestation in both eyes, along with frequent pinworm disc...

PURPOSE To evaluate the cycloplegic effect of 1% tropicamide in myopic children and to determine whether its efficacy is associated with age, gender, iris color, ethnicity, magnitude of the refractive error, or latent error. METHODS Four hundred sixty-nine children enrolled in the Correction of Myopia Evaluation Trial (COMET; a multicenter, randomized, double-masked clinical trial evaluating ...

The effect of topical carteolol 1%, a beta-adrenergic blocker with intrinsic sympathomimetic activity, on the retinal circulation was investigated in 15 normal subjects using laser Doppler velocimetry and monochromatic fundus photography. In a double-masked randomized design, one eye received one drop of carteolol 1% and the fellow eye one drop of placebo. Vessel diameter, maximum erythrocyte v...

PURPOSE To create a standardized method for evaluating the video recordings of patients self-instilling eye drops and to determine the level of agreement of eye drop instillation efficacy, safety and efficiency ratings by three masked graders. DESIGN Prospective cross-sectional study. PARTICIPANTS 78 patients with open-angle glaucoma or ocular hypertension who had at least 6 months of exper...

PURPOSE To assess the prophylactic effect of preoperative application of topical diclofenac on postoperative pain control in patients having photorefractive keratectomy (PRK). SETTING Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN Randomized masked clinical trial. METHODS In this paired-eye study, patients having bilateral PRK received 1 drop of diclofena...

Purpose To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection. Methods CPP toxicity was investigated in cell cultures. Ivit concentrations of ranibizumab and bevacizumab after topical administration were measured using ELISA. The ...

OBJECTIVE The purpose of the study was to evaluate the efficacy of postoperative instruction on proficiency of eye drop instillation following cataract surgery, and to determine whether such proficiency correlates with the prevalence and/or duration of irritation and pain experienced in operated eyes. DESIGN This was a prospective, nonrandomized control trial with an educational intervention ...

Purpose: The aims of this study were to prepare a 0.1% Miconazole (MCZ) eye-drop solution and evaluate the stability physical properties preparation.