We conducted a petrologic study of apatite within eight unbrecciated, non-cumulate eucrites and two monomict, eucrites. These data were combined with previously published to quantify the abundances F, Cl, H2O in bulk silicate portion asteroid 4 Vesta (BSV). Using combination apatite-based melt hygrometry/chlorometry appropriately paired volatile/refractory element ratios, we determined that BSV...

In the cation of the title compound, C(12)H(10)F(2)N(3)O(+)·Cl(-), the dihedral angle between the pyridine and benzene rings is 16.1 (1)°. In the crystal structure, mol-ecules linked into two-dimensional sheets parallel to the bc plane by inter-molecular N-H⋯Cl, C-H⋯Cl and C-H⋯F hydrogen bonds.

The apparent oral clearance (CL/F, mL/min) of busulfan was measured in 279 adolescent and adult patients. Significant (P F .05) determinants of CL/F by linear regression were: actual body weight (BW; r2 5 0.300), body surface area (BSA; r2 5 0.277), adjusted ideal body weight (AIBW; r2 5 0.265), and ideal body weight (IBW; r2 5 0.173); whereas body mass index (BMI), height, age, gender, and dis...

This study aimed to establish a practical and convenient method of predicting intestinal availability (F(g)) in humans for highly permeable compounds at the drug discovery stage, with a focus on CYP3A4-mediated metabolism. We constructed a "simplified F(g) model," described using only metabolic parameters, assuming that passive diffusion is dominant when permeability is high and that the effect...

How many edges can a quadrilateral-free subgraph of a hypercube have? This question was raised by Paul Erdős about 27 years ago. His conjecture that such a subgraph asymptotically has at most half the edges of a hypercube is still unresolved. Let f(n,Cl) be the largest number of edges in a subgraph of a hypercube Qn containing no cycle of length l. It is known that f(n,Cl) = o(|E(Qn)|), when l ...

Two unique organometallic halide series (Ph3P)Au(4-Me-C6H4)(CF3)(X) and (Cy3P)Au(4-F-C6H4)(CF3)(X) (X = I, Br, Cl, F) have been synthesized. The PPh3-supported complexes can undergo both C(aryl)-X and C(aryl)-CF3 reductive elimination. Mechanistic studies of thermolysis at 122 °C reveal a dramatic reactivity and kinetic selectivity dependence on halide ligand. For X = I or F, zero-order kinetic...

The pharmacokinetics of a new selective oestrogen receptor modulator levormeloxifene was investigated in mice, rats, cynomolgus monkeys and humans by compartmental pharmacokinetics. Levormeloxifene was administered as an oral solution in all studies. Allometric scaling was used to predict human pharmacokinetic parameters and the performance of the approach was evaluated. Mean values of clearanc...

Many studies exist on magmatic volatiles (H, C, N, F, S, Cl) in and on the Moon, within the last several years, that have cast into question the post-Apollo view of lunar formation, the distribution and sources of volatiles in the Earth-Moon system, and the thermal and magmatic evolution of the Moon. However, these recent observations are not the first data on lunar volatiles. When Apollo sampl...