BACKGROUND Plasmodium vivax malaria commonly follows treatment of falciparum malaria in regions of co-endemicity. This is an important cause of preventable morbidity. METHODS We examined the factors contributing to the risk of recurrence of P. vivax infection after treatment of acute falciparum malaria in a series of clinical trials conducted on the Thai-Myanmar border from 1991 through 2005....

malaria is a parasitic disease that is starting to be encountered in intensive care units (icu) worldwide, owing to increasing globalisation. severe malaria caused by plasmodium falciparum , is characterised by cerebral malaria, acute renal failure, hypoglycaemia, severe anaemia, splenomegaly and alveolar oedema. we present the case of a 25-yr old male patient who presented to the emergency dep...

background: the number of malaria cases is declining worldwide; however, it remains as a serious health problem. diagnosing unusual cases is the most im­portant issue to manage the problem. this study designed to describe the number of falciparum and vivax malaria infected patients referred to malaria reference labora­tory in tehran university of medical science from 2000 to 2012. methods: a re...

The human malaria parasite Plasmodium falciparum represses transcription of the gene encoding AP2-G, which is master regulator germ cell differentiation, via heterochromatin condensation following histone H3 lysine 9 trimethylation (H3K9me3). Although H3K9me3-marked typically constitutive and its establishment depends on RNA interference (RNAi) pathway in fission yeast centromeres, parasites la...

Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against the parasite. Objective: To determine the immunological impact of hemozoin on the capacity ...

The poor expression of Plasmodium falciparum proteins in heterologous systems and the difficulty in obtaining sufficient material directly from the parasite have limited the experimental characterization of many of the approximately 5200 proteins encoded by this organism. To improve the expression of P. falciparum proteins in the yeast Saccharomyces cerevisiae, we selected yeast ura3 mutants th...

PLASMODIUM FALCIPARUM EBL PROTEINS by JOHN VINCENT STOKES (Under the Direction of David S. Peterson) ABSTRACT While heterologous expression has replaced biochemical purification as the principle method for obtaining purified, authentic proteins for characterization, no single expression system has proven appropriate for all applications. Heterologous expression of Plasmodium falciparum genes ha...

Background Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. This study aimed to determine Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helm...

The major aim of this study was to characterize a soluble Plasmodium falciparum antigen from the plasma of malaria-infected humans and Plasmodium falciparum culture supernatants, using immunoabsorbent techniques and Western blotting. An Mr 60-kDa protein was isolated from the plasma of patients with Plasmodium falciparum malaria by affinity chromatography using rabbit anti-Proteus spp GDH(NADP+...