The recently recognized higher prevalence of pituitary tumours presents a challenge for endocrinologists and health-care resource providers in terms of diagnostics and therapy. The majority of pituitary tumors arise sporadically as anterior pituitary adenomas but approximately 5% can be attributed to a familial syndrome. The clinical and genetic characteristics of familial pituitary adenomas ha...

BACKGROUND Brain arteriovenous malformations (BAVMs) are thought to be sporadic developmental vascular lesions, but familial occurrence has been described. We compared the characteristics of patients with familial BAVMs with those of patients with sporadic BAVMs. METHODS We systematically reviewed the literature on patients with familial BAVMs. Three families that were found in our centre wer...

Purpose: We studied the inheritance pattern, clinical features and outcome in children with vesicoureteral reflux (VUR). Characteristics of known familial VUR cases were also compared with those of sporadic VUR. Material and Methods: 726 patients were treated for VUR between 19902004. The families were contacted by letter inquiring if other members of the family were affected. The phenotype of ...

BACKGROUND/AIMS Familial occurrence of inflammatory bowel disease (IBD) is well documented. Reports from Western countries have shown a higher familial occurrence of ulcerative colitis (UC) in first- and second-degree relatives than that in the Asian UC population. No data are currently available from the Indian subcontinent in this regard. We present our data on the familial aggregation of UC....

INTRODUCTION The histological and immunohistochemical profile of medullary thyroid carcinoma is ill-defined. The objective of this study was to determine the epidemiological, histological, and immunohistochemical characteristics of medullary carcinoma and to analyze whether differences exist between sporadic and familial carcinomas. PATIENTS AND METHODS Fifty-five histologically confirmed tum...