Fetal Alcohol Syndrome (FAS) was first identified as a clinical condition in 1973. FAS has drawn considerable attention in Alaska. During the 1980’s, the Alaska Area Native Health Service of the Indian Health Service began FAS surveillance among beneficiaries. In 1990, the Alaska Area Native Health Service joined the Alaska Department of Health and Social Services and the Centers for Disease Co...

PURPOSE The process of metastasis requires the single tumor cell that seeds the metastatic clone to complete a complex series of steps. Identifying factors responsible for these steps is essential in developing and improving targeted therapy for metastasis. Resistance to receptor-mediated cell death, such as the Fas/Fas ligand pathway, is one mechanism commonly exploited by metastatic cell popu...

Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evalua...

Altered expression of the Fas-Fas ligand apoptotic pathway leads to lymphoproliferative and autoimmune diseases. In lpr/lpr mice and children with autoimmune lymphoproliferative syndrome, defective apoptosis is due to Fas mutations. Large granular lymphocyte (LGL) leukemia is a clonal lymphoproliferative disorder associated with rheumatoid arthritis. Leukemic LGLs are resistant to Fas-dependent...

Fatty acids (FAs) are essential for cell survival, yet their overaccumulation causes lipotoxicity. To prevent lipotoxicity, cells store excess FAs as triglycerides (TGs). In cultured cells TG synthesis is activated by excess unsaturated but not saturated FAs. Here, we identify Ubxd8 as a sensor for unsaturated FAs and regulator of TG synthesis. In cultured cells depleted of FAs, Ubxd8 inhibits ...

Background: Soluble FasL (sFasL) generating from Membrane-bound (mFasL) cleaved by matrix metalloproteinases (MMPs). sFasL inhibits the apoptotic and inflammatory activity of mFasL because competes with binds to Fas. To evaluate serum soluble Fas ligand level in patients chronic myeloid leukemia.
 Materials Method: Serum levels were measured ELISA method after venous blood was collected 56...

Kobieta, spożywając alkohol w czasie ciąży, może przyczynić się do wystąpienia u swojego dziecka problemów natury fizycznej, psychicznej, poznawczej i społecznej. Najbardziej niebezpiecznym powikłaniem jest alkoholowy zespół płodowy (fetal alcohol syndrome, FAS). Ważnym wskaźnikiem poziomu funkcjonowania osób z FAS system składniowy, ponieważ budowa wypowiedzeń stanowi wykładnik umiejętności zd...

Fas-Fas ligand interactions play a central role in the regulation of the immune response. Fas ligand expression by tumors has been implicated in the abrogation of the host antitumor response by killing of Fas-positive effector lymphocytes. We have studied the presence and functional status of Fas and Fas ligand in Ewing's sarcoma. All Ewing's sarcoma cell lines tested expressed Fas on their sur...

To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts res...