Polyamines appear to inhibit peroxidation of vesicles containing acidic phospholipids. A correlation exists between polyamine binding to phospholipid vesicles and its protective effect. However, phosphatidylinositolcontaining vesicles which bind spermine are not protected by the poyamine [Tadolini, Cabrini, Landi, Varani & Pasquali (1985) Biogenic Amines 3, 97-106]. In the present paper I teste...

Polycrystalline samples and single crystals of the complex boride Ti9Fe2Ru18B8 were synthesized by arc-melting the elements and characterized by single-crystal X-ray diffraction and energy-dispersive X-ray analysis. Ti9Fe2Ru18B8 is a new substitutional variant of the Zn11Rh18B8 structure type, space group P4/mbm (No. 127), whose remarkable feature is that it contains one-dimensional chains of d...

Certain DNA sequences are known to be unusually sensitive to nicking via the Fe2+-mediated Fenton reaction. Most notable are a purine nucleotide followed by three or more G residues, RGGG, and purine nucleotides flanking a TG combination, RTGR. Our laboratory previously demonstrated that nicking in the RGGG sequences occurs preferentially 5' to a G residue with the nicking probability decreasin...

The one-step synthesis of three imine boronic esters functionalized with pyridyl groups is described (1a-1c). presence or absence a methyl group affects the whole conformation, being bent “L” linear as determined by X-ray crystal diffraction. C–H⋯O, C–H⋯N, C–H⋯F and C–H … π hydrogen bond interactions support 2D supramolecular arrangements. Ligands were tested metal ion (M2+) sensors in solution...

Exposure of Escherichia coli to H2O2 leads to two kinetically distinguishable modes of killing: mode I killing occurs maximally near 2 mM H2O2, whereas mode II killing is essentially independent of H2O2 concentrations up to 20 mM. A major portion of H2O2 toxicity is attributed to DNA damage caused by the iron-mediated Fenton reaction. By studying DNA damage during Fenton reactions in vitro, the...

A new pyridine-2,3,5,6-tetracarboxylato-bridged Fe(III) complex with a K+ counter ion, K[Fe(H2pdtc)2] (1), was prepared from the reaction of Fe2(SO4)3 · 7H2O, pyridine-2,3,5,6-tetracarboxylic acid and KOH under ambient conditions. The complex has been characterized by singlecrystal and powder X-ray diffraction, IR spectroscopy, TG analysis, elemental analyses, and magnetic measurements. Through...

A series of asymmetrically carboxylate-bridged diiron(ii) complexes featuring fluorine atoms as NMR spectroscopic probes, [Fe2(PIM)(Ar(4F-Ph)CO2)2] (10), [Fe2(F2PIM)(Ar(Tol)CO2)2] (11), and [Fe2(F2PIM)(Ar(4F-Ph)CO2)2] (12), were prepared and characterized by X-ray crystallography, Mössbauer spectroscopy, and VT (19)F NMR spectroscopy. These complexes are part of a rare family of syn N-donor dii...

UNLABELLED BACKGROUND The mitochondrial DNA (mtDNA) lies in close proximity to the free radical-producing electron transport chain, thus, it is highly prone to oxidative damage. Oxyphilic type of follicular thyroid carcinoma consists of cells filled - almost exclusively - with aberrant mitochondria. In turn, bivalent iron (Fe2+) and hydrogen peroxide (H2O2) are indispensable for thyroid horm...

A variety of compounds which bind to Fe have substantial reductions in absorption when co-administered with Fe compounds. The binding of both Fe2+ and Fe3+ ions to pteroylmonoglutamic acid and the pteroylmonoglutamate dianion was examined in vitro. In dimethylsulphoxide (DMSO) alone, pteroylmonoglutamate formed a 2:1 (pteroylmonoglutamate:Fe3+ ion) complex. However, in DMSO-aqueous Bis-Tris buf...