INTRODUCTION Enteral feeding intolerance is a major problem in preterm infants. This study evaluated the safety and efficacy of prophylactic low-dose oral erythromycin, a motilin agonist, as a prokinetic agent in reducing the incidence of this problem. METHODS From February to May 2008, a prospective randomised controlled trial was conducted at the Isfahan University of Medical Sciences, Isfa...

Introduction In critically ill patients early enteral nutrition (EN) preserves gastrointestinal (GI) integrity and motility and should be started as early as possible. We know that several therapeutic strategies, e.g. catecholamines or analgosedation, exert adverse effects on GI motility. What we do not know is whether therapeutic hypothermia has an influence on GI motility and thereby feeding ...

OBJECTIVE To compare the efficacy of combination therapy, with erythromycin and metoclopramide, to erythromycin alone in the treatment of feed intolerance in critically ill patients. DESIGN Randomized, controlled, double-blind trial. SETTING Mixed medical and surgical intensive care unit. PATIENTS Seventy-five mechanically ventilated, medical patients with feed intolerance (gastric residu...

OBJECTIVES To evaluate the effectiveness of high-dose erythromycin to treat feeding intolerance in preterm infants predominantly fed milk formula. DESIGN This study is a prospective randomized controlled trial on 60 premature infants suffering from feeding intolerance. Thirty infants were given oral erythromycin ethylsuccinate at a dose of 50 mg/kg/day for 10 days or until they reached full e...

Although the atherogenic role of dietary cholesterol has been well established, its diabetogenic potential and associated metabolic disturbances have not been reported. Diet-induced hamster models of insulin resistance and dyslipidemia were employed to determine lipogenic and diabetogenic effects of dietary cholesterol. Metabolic studies were conducted in hamsters fed diets rich in fructose (40...

Background: Feed intolerance during early postnatal period is common in newborn with meconium stained aminotic fluid. Present study (A randomized control trail) conducted with an objective to find out incidence of feed intolerance in early postnatal period in term vigorous newborn with MSAF who received gastric lavage as compared with those who not received gastric lavage. Method: Randomized co...

INTRODUCTION A diet containing a high amount of fat has been shown, in short-term studies, to increase the expression of pancreatic lipase and colipase. AIM To investigate the effects of long-term high-fat-feeding (113 days) on the mRNA expression of pancreatic lipase, colipase, pancreatic lipase-related proteins (1 and 2), and uncoupling proteins during the development of obesity and glucose...

BACKGROUND Although the benefits of enteral nutrition in acute pancreatitis are well established, the optimal composition of enteral feeding is largely unknown. The aim of the study was to compare the tolerance and safety of enteral nutrition formulations in patients with acute pancreatitis. METHODS Electronic databases (Scopus, MEDLINE, Cochrane Controlled Clinical Trials Register) and the p...

Enteral nutrition in critically ill patients has been widely debated. Some of the questions include optimal time to begin enteral feeding, gastric versus small-bowel tube placement, and what markers should be used to measure intolerance to enteral nutrition. Although some of these questions are yet to be answered, more evidence has become available since the 1990s to guide practice. For critica...

Malnutrition is common in critically ill patients and is associated with poor outcomes for patients and increased health care spending. Enteral nutrition is the method of choice for nutrition delivery. Enteral nutrition delivery practices vary widely, and underfeeding is widespread in critical care. Interruptions in enteral nutrition due to performance of procedures, positioning, technical issu...