S of the 61 Annual Meeting of the Society of Thrombosis and Hemostasis Research 15-18 February 2017 Basel, Switzerland Investigating the pathomolecular mechanisms an in-frame heterozygous von Willebrand factor large deletion in a von Willebrand disease patient with significant bleeding history H. Yadegari1, N. Marquardt1, V. Ivaskevicius1, O. Rawley2, L. Swystun2, D. Lillicrap2, J. Oldenburg1 (...

1316 June 2014 T novel oral anticoagulation agents (NOACs) include dabigatran, a direct thrombin inhibitor, and rivaroxaban, apixaban, and edoxaban, direct Factor Xa inhibitors, indicated for either stroke prevention with nonvalvular atrial fibrillation or thromboprophylaxis.1,2 The NOACs are administered orally, have predictable onsets within 2 to 4 h, and an offset more rapid than warfarin. A...

Acquired factor VIII (FVIII) inhibitors can cause life-threatening bleeding. Rapid restoration of coagulation is vital. Therapeutic approaches include factor substitution,1,2 immunosuppression (eg, steroids, cyclophosphamide3), and plasmapheresis.4 A novel treatment option is rituximab, a chimeric monoclonal antibody targeting the CD20 antigen and blocking proliferation of normal B cells.5 Rece...

http://dx.doi.org/10.1160/TH16-02-0116 Thromb Haemost 2016; 116: 201–203 Dear Sirs, Considering the high quality of replacement therapy available nowadays for haemophiliacs, the most challenging complication of haemophilia is currently the development of inhibitors, which render replacement therapy ineffective, preclude the access of patients to a safe and effective standard of care (particular...

To the Editor: doses of Mononine, 100 U/kg, and remained clinically stable with inhibitor titers fluctuating between 1 and 8 BU. Nine months after the initiation of the IT regimen, the patient Inhibitors to factor IX (fIX) develop in approximately 1.5% to presented with edema and oliguria. His serum albumin was 0.6 g/ 3% of persons with severe hemophilia B and are commonly associdL. Serum blood...