Prolactin-receptor-deficient mice are a good model in which to study the various actions of prolactin. Female homozygous knockout mice are completely infertile and show a lack of mammary development, while hemizogotes are unable to lactate following their first pregnancy. Male and female homozygotes have markedly elevated serum prolactin levels, and in some instances pituitary hyperplasia is pr...

the angiotensin 1-7 (ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin ii through mas receptor (masr) or other unknown mechanisms. in the current study, the role of masr and steroid hormone estrogen on renal blood flow response to ang 1-7 administration was investigated in ovariectomized (ov) female rats. ov female wistar-rats received estradiol (500 µg/kg/...

The intrauterine position occupied by a rodent fetus influences the amount of testosterone to which it is exposed before birth. Animals that are gestated between two male fetuses (2M) are exposed to higher circulating levels of testosterone than are animals positioned between two female fetuses (2F) and there are reliable differences in the reproductive physiology and behavior of 2M and 2F anim...

Inhibin-like activities in charcoal-treated bovine follicular fluid (FF) and medium from cultured Sertoli cells (SCCM) were assayed in an in nitro bioassay system, using cultured pituitary cells. Addition of both fluids resulted in parallel dose-dependent decreases of the concentration of follicle-stimulating hormone (FSH) in the medium, both in the presence or absence of luteinizing hormone-re...

Male and female rats that were handled from birth to 30 days had increased adrenal weight at weaning. The animals were then rehoused in (a) groups of 10 in a large cage with an enriched environment, (b) a small cage in pairs, or (c) a small cage alone. Isolation advanced and enrichment retarded vaginal opening (in comparison with paired animals) in handled and unhandled females. Puberty was acc...

In regions where leishmaniasis is endemic, clinical disease is usually reported more frequently among males than females. This difference could be due to disparate risks of exposure of males and females, but gender-related differences in the host response to infection may also play a role. Experimental studies of the influence of gender on Leishmania infection have not included parasites of the...

BACKGROUND Senecio biafrae (Asteraceae) is a medicinal plant widely used by traditional healers in the western region of Cameroon for the treatment of female infertility. This experiment was designed to evaluate the effect of the aqueous extract from leaves and stems of S. biafrae (AESb) on the onset of puberty and some biochemical and physiological parameters of reproduction in immature Wistar...

Objectives. To study the effect of toxoplasmas on changes in expression protooncogenes BIRC5, ERBB-2/HER2-NEU, GLI, VEGF and anti-oncogene TP53 rats an experiment depending infection dose period parasite development. Material methods.The was conducted female Wistar to determine survivin (BIRC5), epidermal growth factor (ErbB-2/HER2-Neu), GLI 1, vascular endothelial (VEGF) comparison with refere...