Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome. Fetal demise and growth restrictions were produced after intraperitoneal injection of ethanol to pregnant mice during midgestation (E8). Death and growth abnormalitie...

Establishing a unique neurobehavioural profile for people exposed to alcohol in utero would be a tremendous aid in diagnosis, treatment planning and epidemiological research. Epidemiological studies of fetal alcohol syndrome have shown that only one?third of the babies born to mothers who drank heavily during pregnancy presented with full-blown FAS. 2 Moreover, the majority of people who were e...

Prenatal exposure to alcohol (ethanol) in humans [5] and animals results in a range of alcoholinduced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficienci...

Prenatal exposure to alcohol (ethanol) in humans [5] and animals results in a range of alcoholinduced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficienci...

Alcohol consumption during pregnancy remains common in many countries. Exposure to even low amounts of alcohol (i.e. ethanol) in pregnancy can lead to the heterogeneous fetal alcohol spectrum disorders (FASD), while heavy alcohol consumption can result in the fetal alcohol syndrome (FAS). FAS is characterized by cerebral dysfunction, growth restriction and craniofacial malformations. However, t...

Fetal alcohol syndrome (FAS) is a congenital syndrome caused by maternal alcohol consumption during pregnancy and is entirely preventable by abstinence from alcohol drinking during this time. Little is known about the prevalence of FAS and maternal alcohol consumption during pregnancy in Western countries. We present the results of FAS/partial fetal alcohol syndrome (PFAS) prevalence study and ...

ABBREVIATIONS. FAS, fetal alcohol syndrome; FAE, fetal alcohol effect. Fetal alcohol syndrome (FAS) was first recognized as a distinct clinical entity by Jones and Smith in 1973.' In their first reports, 2,3 all affected children had been born to severely alcoholic women, and had in common problems in three major categories: 1. prenatal and/or postnatal growth deficiency; 2. abnormal brain func...

This study explored relationships between intelligence and visual motor ability and patterns of impairment of visual motor ability in children prenatally affected by alcohol. Fourteen children (mean age 8.2 years) diagnosed with fetal alcohol syndrome (FAS) and 50 children with possible fetal alcohol effects (FAE) were assessed with the Bender Visual Motor Test and a Wechsler IQ test. The group...