BACKGROUND The molecular regulation of heart development is regulated by cis- and trans-factors acting on the genome and epigenome. As a class of important regulatory RNAs, the role of long noncoding RNAs (lncRNAs) in human heart development is still poorly understood. Furthermore, factors that interact with lncRNAs in this process are not well characterized. METHODS AND RESULTS Using RNA seq...

Background: The aim of our study was to evaluate the characteristics of the learning curve of the first trimester (FT) fetal heart scan and to determine the required number of ultrasound examinations for training sonographers to accurately assess the normal fetal heart at 11–13+6 weeks’ gestation, by means of 2D ultrasound. Methods: We selected four trainees (resident doctors) with theoretical ...

Recordings of fetal heart rate provide the clinician with the only non-invasive tool to continuously monitor fetal wellbeing during labour. By far, the most debated component of fetal heart rate monitoring during labour is the significance of fetal heart rate decelerations, which almost invariably occur in association with uterine contractions. Over the years, proposed possible triggers for the...

Univentricular dextrocardia is a rare complex congenital cyanotic heart disease. With the improvement of medical and surgical care, greater number women with diseases have survived up to childbearing age. Pregnancy univentricular Fontan circulation increases maternal fetal mortality morbidity. We report case successful management two pregnancies in woman repaired dextrocardiac heart.

The myocardium contains abundant translatable mRNAs that change during development. Maximal cell-free synthesis of [3H]leucine-, [35S]methionine-, and [35S]cysteine-labeled translation products directed by poly(A)-containing mRNAs from 12-, 14-, and 17-day fetal; 5-day-old neonatal; and 30-day-old adult mouse heart was determined by using one- and two-dimensional polyacrylamide gels. Three gene...

In 1999, a highly publicized report from the Institute of Medicine identified major deficiencies in the United States health care system, which fueled the rapid growth of the modern patient safety movement. One of the greatest risks to patient safety in obstetrics is poor communication of electronic fetal heart rate monitoring findings. Standardization and elimination of unnecessary complexity ...

APPARATUS FOR CONTINUOUS MONITORING OF THE FETAL HEART RATE.* By Edward H. Hon, Department of Obstetrics and Gynecology, Yale University School of Medicine. During the past four years continuous monitoring of fetal heart rate during labor and delivery has permitted the accumulation of accurate, permanent records which may be of value for the assessment of fetal heart rate as an index of fetal e...

rheumatic mitral valve stenosis is the most common form of organic heart disease encountered during pregnancy and continues to cause maternal and fetal mortality. medically refractory congestive heart failure due to mitral stenosis is a clinical challenge and its optimal management remains controversial. on the other hand due to hazard of x-ray to mother and fetus, there are some limitations fo...