1. The binding of 125I-labelled concanavalin A to isolated rat hepatocytes was studied at temperatures between 4 degrees C and 37 degrees C. At the latter temperature, concentrations of concanavalin A from 0.01 to 0.4 mg/ml were used. In all of these experiments, binding reached a plateau after 40--60 min, when 28--35% of the concanavalin A added was bound to the cells (cell density 8 x 10(6) c...

Abstract Background Diabetic retinopathy (DR) is a micro-vascular consequence of diabetes mellitus (DM) that manifests clinically as retinal ischemia, neovascularization, altered permeability, and macular edema. In the adult population, DR now considered leading cause blindness. Fetuin-A multifunctional glycoprotein that, because its dual role in insulin resistance angiogenesis, could be an ear...

We read the article, entitled “Association of mitral annular calcification with endothelial dysfunction, carotid intima-media thickness, and serum fetuin-A: An observational study,” by Ziyrek et al. (1) in Anatolian J Cardiol 2013; 13: 752-8, in which they reported that their findings might reflect a close association between mitral annular calcification and cardiovascular risk factors in patie...

OBJECTIVE This study evaluated the sex-specific association of plasma fetuin-A levels with prevalent and incident type 2 diabetes in community-dwelling older adults. RESEARCH DESIGN AND METHODS Participants were 684 men and 1,058 women (median age, 71 years) whose fetuin-A levels, diabetes prevalence, and diabetes risk factors were evaluated in 1992-1996. The participants were followed for in...

Inflammation and genetics have key roles in the pathogenesis of atherosclerosis, and the etiology of myocardial infarction (MI). Recent studies have indicated that lower serum levels of fetuin-A may accelerate the vascular mineralization process, which leads to pathophysiological conditions, such as coronary heart disease and chronic renal failure. The aim of the present study was to evaluate t...

Objective: Young adults with type 2 diabetes were demonstrated to have increased cardiovascular disease risk. Fetuin-A levels are associated with insulin resistance, impaired glucose tolerance, hepatosteatosis, subclinical inflammation and increased cardiovascular risk. Apolipoprotein (Apo) B/Apo A1 ratio is a well-defined cardiovascular risk assessment marker. In this study, we aimed to invest...

BACKGROUND The secreted liver protein fetuin-A (AHSG) is up-regulated in hepatic steatosis and the metabolic syndrome. These states are strongly associated with low-grade inflammation and hypoadiponectinemia. We, therefore, hypothesized that fetuin-A may play a role in the regulation of cytokine expression, the modulation of adipose tissue expression and plasma concentration of the insulin-sens...

BACKGROUND Fetuin-A, a protein secreted primarily by the liver, has been associated with nonalcoholic fatty liver disease and insulin resistance. In a recent study, higher circulating fetuin-A was associated with cardiovascular events, particularly ischemic stroke. However, these data have not been replicated. METHODS A nested case control design was used to examine the relationship between f...

The present studies show that the previously reported ability of fetuin to inhibit the precipitation of hydroxyapatite from supersaturated solutions of calcium and phosphate in vitro is accompanied by the formation of the fetuin-mineral complex, a high molecular mass complex of calcium phosphate mineral and the proteins fetuin and matrix Gla protein that was initially discovered in the serum of...